ArticleNature communications2018
Click chemistry enables quantitative chiroptical sensing of chiral compounds in protic media and complex mixtures.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Chiral Analysis for High-Throughput Reaction Screening: Recent Advances in Accelerating Asymmetric Catalysis Discovery.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Integrating Catalysis and Analysis: Accelerated Asymmetric Reaction Development With a Multitasking Reactivity Umpolung/Chiroptical Reporter Auxiliary.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Determination of the Molar Fraction and Enantiomeric Excess of Electrosprayed Amino Acid Anions Employing Photoelectron Circular Dichroism.Analytical chemistry · 2025Article
- A stereodynamic probe of Pt(II) molecular hinge for chiroptical sensing of cryptochiral compounds.Nature communications · 2025Article
- Optical Enantiodifferentiation of Chiral Nitriles.Organic letters · 2024Article
- Article
- Design of mechanical-robust phosphorescence materials through covalent click reaction.Nature communications · 2023Article
- High-throughput determination of enantiopurity in atroposelective synthesis of aryl triazoles.Chemical science · 2023Article
- A Racemic Naphthyl-Coumarin-Based Probe for Quantitative Enantiomeric Excess Analysis of Amino Acids and Enantioselective Sensing of Amines and Amino Alcohols.ChemistryOpen · 2022Article
- Optical deciphering of multinary chiral compound mixtures through organic reaction based chemometric chirality sensing.Nature communications · 2021Article
- Advancement in Organic Synthesis through High Throughput Experimentation.Chemistry methods : new approaches to solving problems in chemistry · 2021Article
- Chemoselective bioconjugation based on modular click chemistry with 4-halocoumarins and aryl sulfonates.RSC advances · 2021Article
- A rapid and sensitive method for chiroptical sensing of α-amino acidsChemical science · 2020Article
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Authors and funding
3 authors.
Funding
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Abstract
Click reactions have become powerful synthetic tools with unique applications in the health and materials sciences. Despite the progress with optical sensors that exploit the principles of dynamic covalent chemistry, metal coordination or supramolecular assemblies, quantitative analysis of complex mixtures remains challenging. Herein, we report the use of a readily available coumarin conjugate acceptor for chiroptical click chirality sensing of the absolute configuration, concentration and enantiomeric excess of several compound classes. This method has several attractive features, including wide scope, fast substrate fixation without by-product formation or complicate equilibria often encountered in reversible substrate binding, excellent solvent compatibility, and tolerance of air and water. The ruggedness and practicality of this approach are demonstrated by comprehensive analysis of nonracemic monoamine samples and crude asymmetric imine hydrogenation mixtures without work-up. Click chemosensing addresses increasingly important time efficiency, cost, labor and chemical sustainability aspects and streamlines asymmetric reaction development at the mg scale.
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Registered trials
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