Evidence map›Paper›PMID 30552295›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2019

Synthetic Cannabinoid Hydroxypentyl Metabolites Retain Efficacy at Human Cannabinoid Receptors.

Thomas F Gamage, Charlotte E Farquhar, Ryan J McKinnie, Richard C Kevin, Iain S McGregor, Mark L Trudell, Jenny L Wiley, Brian F Thomas

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 38 citations in OpenAlex.

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  7. Linking in vitro and ex vivo CBArchives of toxicology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Thomas F GamageRTI International, Research Triangle Park, North Carolina (T.F.G., C.E.F., J.L.W., B.F.T.); Department of Chemistry, University of New Orleans, New Orleans, Louisiana (R.J.M., M.L.T.); and School of Psychology, University of Sydney, Sydney, New South Wales, Australia (R.C.K., I.S.M.).ORCID 0000-0003-3528-9695
Charlotte E FarquharRTI International, Research Triangle Park, North Carolina (T.F.G., C.E.F., J.L.W., B.F.T.); Department of Chemistry, University of New Orleans, New Orleans, Louisiana (R.J.M., M.L.T.); and School of Psychology, University of Sydney, Sydney, New South Wales, Australia (R.C.K., I.S.M.).
Ryan J McKinnieRTI International, Research Triangle Park, North Carolina (T.F.G., C.E.F., J.L.W., B.F.T.); Department of Chemistry, University of New Orleans, New Orleans, Louisiana (R.J.M., M.L.T.); and School of Psychology, University of Sydney, Sydney, New South Wales, Australia (R.C.K., I.S.M.).
Richard C KevinRTI International, Research Triangle Park, North Carolina (T.F.G., C.E.F., J.L.W., B.F.T.); Department of Chemistry, University of New Orleans, New Orleans, Louisiana (R.J.M., M.L.T.); and School of Psychology, University of Sydney, Sydney, New South Wales, Australia (R.C.K., I.S.M.).
Iain S McGregorRTI International, Research Triangle Park, North Carolina (T.F.G., C.E.F., J.L.W., B.F.T.); Department of Chemistry, University of New Orleans, New Orleans, Louisiana (R.J.M., M.L.T.); and School of Psychology, University of Sydney, Sydney, New South Wales, Australia (R.C.K., I.S.M.).
Mark L TrudellRTI International, Research Triangle Park, North Carolina (T.F.G., C.E.F., J.L.W., B.F.T.); Department of Chemistry, University of New Orleans, New Orleans, Louisiana (R.J.M., M.L.T.); and School of Psychology, University of Sydney, Sydney, New South Wales, Australia (R.C.K., I.S.M.).
Jenny L WileyRTI International, Research Triangle Park, North Carolina (T.F.G., C.E.F., J.L.W., B.F.T.); Department of Chemistry, University of New Orleans, New Orleans, Louisiana (R.J.M., M.L.T.); and School of Psychology, University of Sydney, Sydney, New South Wales, Australia (R.C.K., I.S.M.).
Brian F ThomasRTI International, Research Triangle Park, North Carolina (T.F.G., C.E.F., J.L.W., B.F.T.); Department of Chemistry, University of New Orleans, New Orleans, Louisiana (R.J.M., M.L.T.); and School of Psychology, University of Sydney, Sydney, New South Wales, Australia (R.C.K., I.S.M.) bft@rti.org.
University of Sydney · AURTI International · USUniversity of New Orleans · US

Funding

THC RECEPTORSR01DA003672 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI WILEY, JENNY L. · 1985 to 2018
$4.9M
Investigation of Synthetic Cannabinoid Exposures and Pharmacological ConsequencesR01DA040460 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI RANGAN MAITRA, Yanan Zhang · 2016 to 2026
$4.5M
In vitro and in vivo characterization of CB1 allosteric modulatorsK01DA045752 · NIDA · UPSTATE MEDICAL UNIVERSITY · PI GAMAGE, THOMAS F · 2018 to 2022
$807k
NIDA NIH HHS K01 DA045752NIDA NIH HHS R01 DA003672NIDA NIH HHS R01 DA040460
6 · The paper itself

Abstract

Synthetic cannabinoids (SCs) are novel psychoactive substances that are easily acquired, widely abused as a substitute for cannabis, and associated with cardiotoxicity and seizures. Although the structural bases of these compounds are scaffolds with known affinity and efficacy at the human cannabinoid type-1 receptor (hCB

Indexed as

CannabinoidsCyclohexanolsDose-Response Relationship, DrugHEK293 CellsHumansProtein BindingReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2Synthetic Drugs3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanolCannabinoidsCyclohexanolsReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2Synthetic Drugs

Identifiers

PMID30552295
PMCPMC6374541
OpenAlexW2903891151

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.