Evidence map›Paper›PMID 30552234›Full record

ArticleMolecular cancer research : MCR2019

Unraveling the Cellular Mechanism of Assembling Cholesterols for Selective Cancer Cell Death.

Huaimin Wang, Zhaoqianqi Feng, Cuihong Yang, Jinjian Liu, Jamie E Medina, S Ali Aghvami, Daniela M Dinulescu, Jianfeng Liu, Seth Fraden, Bing Xu

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer research : MCR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
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  7. Enzymatic Noncovalent Synthesis.Chemical reviews · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Huaimin WangDepartment of Chemistry, Brandeis University, Waltham, Massachusetts.
Zhaoqianqi FengDepartment of Chemistry, Brandeis University, Waltham, Massachusetts.
Cuihong YangChinese Academy of Medical Science & Peking Union Medical College, Tianjin, China.
Jinjian LiuChinese Academy of Medical Science & Peking Union Medical College, Tianjin, China.
Jamie E MedinaDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
S Ali AghvamiDepartment of Physics, Brandeis University, Waltham, Massachusetts.
Daniela M DinulescuDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Jianfeng LiuChinese Academy of Medical Science & Peking Union Medical College, Tianjin, China.
Seth FradenDepartment of Physics, Brandeis University, Waltham, Massachusetts.
Bing XuDepartment of Chemistry, Brandeis University, Waltham, Massachusetts. bxu@brandeis.edu.
Harvard University · US

Funding

Subcellular Enzyme-instructed self-assembly for molecular anticancer nanomedicinesR01CA142746 · NCI · BRANDEIS UNIVERSITY · PI Bing Xu · 2010 to 2026
$6.4M
Overcoming Tumor Resistance with Enzyme-Instructed Nanoscale Assemblies and ImmunotherapiesF99CA234746 · NCI · BRANDEIS UNIVERSITY · PI FENG, ZHAOQIANQI · 2018 to 2019
$62k
NCI NIH HHS F99 CA234746NCI NIH HHS R01 CA142746
6 · The paper itself

Abstract

Acquired drug resistance remains a challenge in chemotherapy. Here we show enzymatic,

Indexed as

ActinsAnimalsAntineoplastic AgentsCell DeathCell Line, TumorCholesterolCisplatinDoxorubicinDrug Resistance, NeoplasmEndoplasmic Reticulum StressHeLa CellsHep G2 CellsHumansMiceMice, Inbred BALB CMitochondrial DynamicsActinsAntineoplastic AgentsCholesterolCisplatinDoxorubicinProto-Oncogene Proteins c-aktsrc-Family Kinases

Identifiers

PMID30552234
PMCPMC6445745
OpenAlexW2905410102

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.