ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Phase-Dependent Suppression of Beta Oscillations in Parkinson's Disease Patients.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 120 citations in OpenAlex.
- Stimulation-evoked orbitofrontal activity as a biomarker for DBS personalization in depression.medRxiv : the preprint server for health sciences · 2026Article
- A Canonical Neural Map and Its Deviations Shape Parkinson's Disease Phenotypes.Research square · 2026Article
- Separable global and local beta burst dynamics in motor cortex of primates.bioRxiv : the preprint server for biology · 2025Article
- Computational model for control of hand movement in Parkinson's disease using deep brain stimulation.Experimental brain research · 2025Article
- Site-specific seeding of Lewy pathology induces distinct pre-motor cellular and dendritic vulnerabilities in the cortex.Nature communications · 2024Article
- Unraveling the Complexity of Parkinson's Disease: Insights into Pathogenesis and Precision Interventions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- How to design optimal brain stimulation to modulate phase-amplitude coupling?Journal of neural engineering · 2024Article
- Mathematical derivation and mechanism analysis of beta oscillations in a cortex-pallidum model.Cognitive neurodynamics · 2024Article
- Modulation of DBS-induced cortical responses and movement by the directionality and magnitude of current administered.NPJ Parkinson's disease · 2024Article
- Closing the loop in psychiatric deep brain stimulation: physiology, psychometrics, and plasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Feedback control of collective dynamics in an oscillator population with time-dependent connectivity.Frontiers in network physiology · 2024Article
- Dynamics of parkinsonian oscillations mediated by transmission delays in a mean-field model of the basal ganglia.Frontiers in cellular neuroscience · 2024Article
- From dawn till dusk: Time-adaptive bayesian optimization for neurostimulation.PLoS computational biology · 2023Article
- Open Hardware Implementation of Real-Time Phase and Amplitude Estimation for Neurophysiologic Signals.Bioengineering (Basel, Switzerland) · 2023Article
- Advances in Deep Brain Stimulation: From Mechanisms to Applications.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
- Closed-loop optogenetic control of the dynamics of neural activity in non-human primates.Nature biomedical engineering · 2023Article
- Lactiplantibacillus plantarum PS128 Alleviates Exaggerated Cortical Beta Oscillations and Motor Deficits in the 6-Hydroxydopamine Rat Model of Parkinson's Disease.Probiotics and antimicrobial proteins · 2023Article
- Parkinsonian daytime sleep-wake classification using deep brain stimulation lead recordings.Neurobiology of disease · 2023Article
- Stable, interactive modulation of neuronal oscillations produced through brain-machine equilibrium.Cell reports · 2022Article
- No evidence of rhythmic visuospatial attention at cued locations in a spatial cuing paradigm, regardless of their behavioural relevance.The European journal of neuroscience · 2022Article
Corrections and comments
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Authors and funding
17 authors at 7 institutions in 5 countries.
Funding
Abstract
Synchronized oscillations within and between brain areas facilitate normal processing, but are often amplified in disease. A prominent example is the abnormally sustained beta-frequency (∼20 Hz) oscillations recorded from the cortex and subthalamic nucleus of Parkinson's disease patients. Computational modeling suggests that the amplitude of such oscillations could be modulated by applying stimulation at a specific phase. Such a strategy would allow selective targeting of the oscillation, with relatively little effect on other activity parameters. Here, activity was recorded from 10 awake, parkinsonian patients (6 male, 4 female human subjects) undergoing functional neurosurgery. We demonstrate that stimulation arriving on a particular patient-specific phase of the beta oscillation over consecutive cycles could suppress the amplitude of this pathophysiological activity by up to 40%, while amplification effects were relatively weak. Suppressive effects were accompanied by a reduction in the rhythmic output of subthalamic nucleus (STN) neurons and synchronization with the mesial cortex. While stimulation could alter the spiking pattern of STN neurons, there was no net effect on firing rate, suggesting that reduced beta synchrony was a result of alterations to the relative timing of spiking activity, rather than an overall change in excitability. Together, these results identify a novel intrinsic property of cortico-basal ganglia synchrony that suggests the phase of ongoing neural oscillations could be a viable and effective control signal for the treatment of Parkinson's disease. This work has potential implications for other brain diseases with exaggerated neuronal synchronization and for probing the function of rhythmic activity in the healthy brain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.