Evidence map›Paper›PMID 30552164›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2019

Aging of Antiviral CD8

Bennett Davenport, Jens Eberlein, Verena van der Heide, Kevin Jhun, Tom T Nguyen, Francisco Victorino, Andrew Trotta, Jerry Chipuk, Zhengzi Yi, Weijia Zhang and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Proteostasis in T cell aging.Seminars in immunology · 2023
    Review
  7. Review
  8. Article
  9. Article
  10. CD8Nature reviews. Immunology · 2021
    Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Metabolic characteristics of CD8Nature communications · 2020
    Article
  17. Article
  18. Article
  19. The clock is ticking: the impact of ageing on T cell metabolism.Clinical & translational immunology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Bennett DavenportDepartment of Anesthesiology, University of Colorado Denver, Aurora, CO 80045.
Jens EberleinDepartment of Anesthesiology, University of Colorado Denver, Aurora, CO 80045.ORCID 0000-0002-6268-1767
Verena van der HeideDiabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.ORCID 0000-0002-3602-4405
Kevin JhunDiabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.ORCID 0000-0002-1677-2297
Tom T NguyenDepartment of Anesthesiology, University of Colorado Denver, Aurora, CO 80045.
Francisco VictorinoDepartment of Anesthesiology, University of Colorado Denver, Aurora, CO 80045.
Andrew TrottaDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029; and.
Jerry ChipukDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029; and.
Zhengzi YiBioinformatics Laboratory, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Weijia ZhangBioinformatics Laboratory, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Eric T ClambeyDepartment of Anesthesiology, University of Colorado Denver, Aurora, CO 80045.ORCID 0000-0002-7972-9544
Donald K ScottDiabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Dirk HomannDepartment of Anesthesiology, University of Colorado Denver, Aurora, CO 80045; dirk.homann@mssm.edu.ORCID 0000-0002-7622-5754
Icahn School of Medicine at Mount Sinai · USNational Jewish Health · USUniversity of Colorado Health · US

Funding

UCHSC DIABETES ENDOCRINOLOGY RESEARCH CENTERP30DK057516 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI HUTTON, JOHN C · 2000 to 2010
$14.0M
TRAINING PROGRAM IN IMMUNOLOGYT32AI007405 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Laurel L Lenz, Raul Martin Torres · 1991 to 2026
$10.5M
Molecular Pathogenesis of Infectious DiseasesT32AI052066 · NIAID · UNIVERSITY OF COLORADO DENVER · PI VAN DYK, LINDA F. · 2002 to 2022
$2.3M
TRAINING PROGRAM IN INVESTIGATIVE GASTROENTEROLOGYT32DK007792 · NIDDK · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI CHO, JUDY H. · 2001 to 2016
$2.3M
Regulation of Pathogen-specific T Cell Immunity by Adenosine GenerationR01AI093637 · NIAID · UNIVERSITY OF COLORADO DENVER · PI HOMANN, DIRK · 2012 to 2016
$2.0M
Transforming Genomics with 5 PB Big Omics Data Engine Cray CS300-AC SupercomputerS10OD018522 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2014 to 2014
$1.9M
(PQ5) Role of Mitochondrial Division in Cancer BiologyR01CA206005 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHIPUK, JERRY EDWARD · 2016 to 2020
$1.7M
Maturation of established antiviral CD8 T cell memoryR21AG026518 · NIA · UNIVERSITY OF COLORADO DENVER · PI HOMANN, DIRK · 2005 to 2006
$343k
NCI NIH HHS R01 CA206005NIAID NIH HHS R01 AI093637NIAID NIH HHS T32 AI007405NIAID NIH HHS T32 AI052066NIA NIH HHS R21 AG026518NIDDK NIH HHS P30 DK057516NIDDK NIH HHS T32 DK007792NIH HHS S10 OD018522
6 · The paper itself

Abstract

Aging of established antiviral T cell memory can foster a series of progressive adaptations that paradoxically improve rather than compromise protective CD8

Indexed as

AgingAnimalsAntigens, ViralCD8-Positive T-LymphocytesCell MovementCells, CulturedCell SurvivalImmunologic MemoryLymph NodesLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMiceMice, Inbred C57BLMice, TransgenicReceptors, Antigen, T-CellAntigens, ViralReceptors, Antigen, T-Cell

Identifiers

PMID30552164
PMCPMC6358025
OpenAlexW2756771535

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.