Evidence map›Paper›PMID 30552162›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2019

Hif-1α-Induced Expression of Il-1β Protects against Mycobacterial Infection in Zebrafish.

Nikolay V Ogryzko, Amy Lewis, Heather L Wilson, Annemarie H Meijer, Stephen A Renshaw, Philip M Elks

Open access · hybridAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 91 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Cells · 2026
    Article
  5. Evaluation of the Health Status of Largemouth Bass (Animals : an open access journal from MDPI · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. ENO1 fromBiomolecules · 2025
    Article
  14. Review
  15. Article
  16. Macrophage adaptation to hypoxia: metabolism, migration, and phagocytosis.Frontiers in cellular and infection microbiology · 2025
    Article
  17. Frontiers in tuberculosis · 2025
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Nikolay V OgryzkoThe Bateson Centre, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom.ORCID 0000-0003-0199-5567
Amy LewisThe Bateson Centre, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom.ORCID 0000-0002-1156-3592
Heather L WilsonDepartment of Infection and Immunity and Cardiovascular Disease, University of Sheffield, Western Bank, Sheffield S10 2RX, United Kingdom; and.ORCID 0000-0002-7892-3425
Annemarie H MeijerInstitute of Biology, Leiden University, 2333 CC Leiden, the Netherlands.ORCID 0000-0002-1325-0725
Stephen A RenshawThe Bateson Centre, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom.ORCID 0000-0003-1790-1641
Philip M ElksThe Bateson Centre, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom; p.elks@sheffield.ac.uk.ORCID 0000-0003-1683-0749
University of Sheffield · GBCentre for Inflammation Research · GBLeiden University · NL

Funding

Biotechnology and Biological Sciences Research Council BB/L000830/1British Heart Foundation PG/13/80/30443Medical Research Council MR/M004864/1Wellcome Trust 105570
6 · The paper itself

Abstract

Drug-resistant mycobacteria are a rising problem worldwide. There is an urgent need to understand the immune response to tuberculosis to identify host targets that, if targeted therapeutically, could be used to tackle these currently untreatable infections. In this study we use an Il-1β fluorescent transgenic line to show that there is an early innate immune proinflammatory response to well-established zebrafish models of inflammation and

Indexed as

AnimalsAnimals, Genetically ModifiedAntitubercular AgentsCells, CulturedClustered Regularly Interspaced Short Palindromic RepeatsDisease Models, AnimalGene Knockout TechniquesGreen Fluorescent ProteinsHumansHypoxiaHypoxia-Inducible Factor 1, alpha SubunitImmunity, InnateInterleukin-1betaMacrophagesMycobacterium Infections, NontuberculousMycobacterium marinumAntitubercular AgentsGreen Fluorescent Proteinshif1aa protein, zebrafishHypoxia-Inducible Factor 1, alpha SubunitInterleukin-1betaNitric Oxide

Identifiers

PMID30552162
PMCPMC6321843
OpenAlexW2952929850

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.