ArticleThe Journal of biological chemistry2019
Transcriptional profiling of isogenic Friedreich ataxia neurons and effect of an HDAC inhibitor on disease signatures.
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Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
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Who cites it
25 citing papers in PubMed, 36 citations in OpenAlex.
- Friedreich ataxia transcriptomic dysregulation and identification of cell type-specific biomarkers: A systematic review and meta-analysis.bioRxiv : the preprint server for biology · 2026Article
- Human pluripotent stem cell models of Friedreich's ataxia: innovations, considerations, and future perspectives.Stem cell research & therapy · 2026Review
- A global perspective on research advances and future challenges in Friedreich ataxia.Nature reviews. Neurology · 2025Review
- Differential Gene Expression in Late-Onset Friedreich Ataxia: A Comparative Transcriptomic Analysis Between Symptomatic and Asymptomatic Sisters.International journal of molecular sciences · 2024Article
- Skeletal Muscle Involvement in Friedreich Ataxia.International journal of molecular sciences · 2024Review
- Gene editing improves endoplasmic reticulum-mitochondrial contacts and unfolded protein response in Friedreich's ataxia iPSC-derived neurons.Frontiers in pharmacology · 2024Article
- Exploring the dynamic interplay between cancer stem cells and the tumor microenvironment: implications for novel therapeutic strategies.Journal of translational medicine · 2023Review
- Patient-derived iPSC models of Friedreich ataxia: a new frontier for understanding disease mechanisms and therapeutic application.Translational neurodegeneration · 2023Review
- Skeletal muscle transcriptomics dissects the pathogenesis of Friedreich's ataxia.Human molecular genetics · 2023Article
- Blood RNA transcripts reveal similar and differential alterations in fundamental cellular processes in Alzheimer's disease and other neurodegenerative diseases.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Proprioceptors-enriched neuronal cultures from induced pluripotent stem cells from Friedreich ataxia patients show altered transcriptomic and proteomic profiles, abnormal neurite extension, and impaired electrophysiological properties.Brain communications · 2023Article
- Frataxin deficiency alters gene expression in Friedreich ataxia derived IPSC-neurons and cardiomyocytes.Molecular genetics & genomic medicine · 2023Article
- Skeletal muscle proteome analysis underpins multifaceted mitochondrial dysfunction in Friedreich's ataxia.Frontiers in neuroscience · 2023Article
- Blood Transcript Biomarkers Selected by Machine Learning Algorithm Classify Neurodegenerative Diseases including Alzheimer's Disease.Biomolecules · 2022Article
- A non-synonymous single nucleotide polymorphism inFrontiers in molecular biosciences · 2022Article
- Perspectives on current models of Friedreich's ataxia.Frontiers in cell and developmental biology · 2022Article
- Patient-derived iPSC modeling of rare neurodevelopmental disorders: Molecular pathophysiology and prospective therapies.Neuroscience and biobehavioral reviews · 2021Review
- Reverse Phase Protein Array Reveals Correlation of Retinoic Acid Metabolism With Cardiomyopathy in Friedreich's Ataxia.Molecular & cellular proteomics : MCP · 2021Article
- Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells.The Journal of biological chemistry · 2020Article
- Frataxin gene editing rescues Friedreich's ataxia pathology in dorsal root ganglia organoid-derived sensory neurons.Nature communications · 2020Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Jiun-I LaiFrom the Departments of Molecular Medicine and.
Daniel Nachunthe Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, California 90095.
Lina PetrosyanFrom the Departments of Molecular Medicine and.
Benjamin ThroeschNeuroscience, The Scripps Research Institute, La Jolla, California 92037 and.
Erica CampauFrom the Departments of Molecular Medicine and.
Fuying Gaothe Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, California 90095.
Kristin K BaldwinNeuroscience, The Scripps Research Institute, La Jolla, California 92037 and.
Giovanni Coppolathe Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, California 90095.ORCID 0000-0003-2105-1061
Joel M GottesfeldFrom the Departments of Molecular Medicine and.ORCID 0000-0002-4643-5777
Elisabetta SoragniFrom the Departments of Molecular Medicine and soragni@scripps.edu.
Scripps Research Institute · USCenter for Neurosciences · US
Funding
Integrative Center for Neurogenetics and Neurogenomics - OverallP30NS062691 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ESKIN, ELEAZAR · 2009 to 2018
$7.4MDefining a transcriptional periodic table of the human brain using reprogrammingDP1AG055944 · NIA · SCRIPPS RESEARCH INSTITUTE, THE · PI BALDWIN, KRISTIN KAY · 2016 to 2020
$7.2MMechanisms of Gene Silencing of Friedreich's AtaxiaR01NS062856 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI GOTTESFELD, JOEL M. · 2009 to 2018
$4.1MGenome-wide investigation of somatic mutation in the developing and aging brainR01MH102698 · NIMH · SCRIPPS RESEARCH INSTITUTE, THE · PI BALDWIN, KRISTIN KAY, HALL, IRA M · 2014 to 2018
$3.4MThe architecture and development of a sensory processing circuit for smellR01DC012592 · NIDCD · SCRIPPS RESEARCH INSTITUTE, THE · PI BALDWIN, KRISTIN KAY · 2012 to 2016
$2.3MNIA NIH HHS DP1 AG055944NIDCD NIH HHS R01 DC012592NIMH NIH HHS R01 MH102698NINDS NIH HHS P30 NS062691NINDS NIH HHS R01 NS062856
Abstract
Friedreich ataxia (FRDA) is a neurodegenerative disorder caused by transcriptional silencing of the frataxin (
Indexed as
TranscriptomeCells, CulturedFrataxinFriedreich AtaxiaGene EditingGene Expression ProfilingHistone Deacetylase InhibitorsHumansInduced Pluripotent Stem CellsIron-Binding ProteinsNeuronsTrinucleotide Repeat ExpansionFrataxinHistone Deacetylase InhibitorsIron-Binding ProteinsFriedreich ataxiagene editinghistone deacetylase inhibitor (HDAC inhibitor)induced pluripotent stem cell (iPS cell) (iPSC)neurodegenerationneuronrepeat expansiontranscriptomics
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.