ReviewThe Journal of cell biology2019
Opening the black box: Stem cell-based modeling of human post-implantation development.
Review in The Journal of cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- The endo-lysosomal system drives lumen formation in a human epiblast model.Nature communications · 2026Article
- Amniogenesis in embryos and stem cell models.Nature cell biology · 2026Review
- CLDN10-driven lineage decision in an amnion and primordial germ cell progenitor at the amnion-epiblast boundary in primates.Genome biology · 2025Article
- Matrigel inhibits elongation and drives endoderm differentiation in aggregates of mouse embryonic stem cells.FEBS open bio · 2025Article
- Three-Dimensional Models of Implantation Using Human Stem Cells: Scientific Insights and Broader Considerations.Biomolecules · 2025Review
- Primate amnion development.Development (Cambridge, England) · 2024Review
- Temporally resolved single cell transcriptomics in a human model of amniogenesis.bioRxiv : the preprint server for biology · 2024Article
- Article
- Temporally resolved early BMP-driven transcriptional cascade during human amnion specification.bioRxiv : the preprint server for biology · 2024Article
- Wnt and BMP signalling direct anterior-posterior differentiation in aggregates of mouse embryonic stem cells.Biology open · 2023Article
- Derivation of Human Extraembryonic Mesoderm-like Cells from Primitive Endoderm.International journal of molecular sciences · 2023Article
- Monitoring Effects of Membrane Traffic Via Changes in Cell Polarity and Morphogenesis in Three-Dimensional Human Pluripotent Stem Cell Cysts.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Human epiblast lumenogenesis: From a cell aggregate to a lumenal cyst.Seminars in cell & developmental biology · 2022Review
- Glutamine-dependent signaling controls pluripotent stem cell fate.Developmental cell · 2022Article
- Machine learning-assisted imaging analysis of a human epiblast model.Integrative biology : quantitative biosciences from nano to macro · 2021Article
- Modeling human embryo development with embryonic and extra-embryonic stem cells.Developmental biology · 2021Review
- Biomedical and societal impacts of in vitro embryo models of mammalian development.Stem cell reports · 2021Review
- Spatially resolved cell polarity proteomics of a human epiblast model.Science advances · 2021Article
- Human Embryo Models and Drug Discovery.International journal of molecular sciences · 2021Review
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Proper development of the human embryo following its implantation into the uterine wall is critical for the successful continuation of pregnancy. However, the complex cellular and molecular changes that occur during this post-implantation period of human development are not amenable to study in vivo. Recently, several new embryo-like human pluripotent stem cell (hPSC)-based platforms have emerged, which are beginning to illuminate the current black box state of early human post-implantation biology. In this review, we will discuss how these experimental models are carving a way for understanding novel molecular and cellular mechanisms during early human development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.