Evidence map›Paper›PMID 30552096›Full record

ArticleEMBO molecular medicine2019

APOPT1/COA8 assists COX assembly and is oppositely regulated by UPS and ROS.

Alba Signes, Raffaele Cerutti, Anna S Dickson, Cristiane Benincá, Elizabeth C Hinchy, Daniele Ghezzi, Rosalba Carrozzo, Enrico Bertini, Michael P Murphy, James A Nathan and 3 more

Open access · goldAbstract read
In one paragraph

Article in EMBO molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Mitochondrial CytochromeFrontiers in cell and developmental biology · 2022
    Article
  10. Tackling Dysfunction of Mitochondrial Bioenergetics in the Brain.International journal of molecular sciences · 2021
    Review
  11. Mitochondrial Structure and Bioenergetics in Normal and Disease Conditions.International journal of molecular sciences · 2021
    Review
  12. Review
  13. Article
  14. Mitochondrial diseases: expanding the diagnosis in the era of genetic testing.Journal of translational genetics and genomics · 2020
    Article
  15. Knockdown ofFrontiers in physiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Alba SignesMRC-Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
Raffaele CeruttiMRC-Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
Anna S DicksonDepartment of Medicine, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
Cristiane BenincáMRC-Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
Elizabeth C HinchyMRC-Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
Daniele GhezziUnit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Italy.ORCID 0000-0002-9358-1566
Rosalba CarrozzoUnit of Neuromuscular and Neurodegenerative Disorders, Bambino Gesù Children's Research Hospital, IRCCS, Rome, Italy.
Enrico BertiniUnit of Neuromuscular and Neurodegenerative Disorders, Bambino Gesù Children's Research Hospital, IRCCS, Rome, Italy.ORCID 0000-0001-9276-4590
Michael P MurphyMRC-Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
James A NathanDepartment of Medicine, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.ORCID 0000-0002-0248-1632
Carlo ViscomiMRC-Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0001-6050-0566
Erika Fernandez-VizarraMRC-Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK emfvb2@mrc-mbu.cam.ac.uk mdz21@mrc-mbu.cam.ac.uk.ORCID 0000-0002-2469-142X
Massimo ZevianiMRC-Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK emfvb2@mrc-mbu.cam.ac.uk mdz21@mrc-mbu.cam.ac.uk.ORCID 0000-0002-9067-5508
University of Cambridge · GBBambino Gesù Children's Hospital · ITUniversity of Milan · IT

Funding

Medical Research Council MC_UP_1002/1Medical Research Council MC_UU_00015/3Medical Research Council MC_UU_00015/5Medical Research Council MC_UU_00015/7Medical Research Council MC_UU_00015/8Wellcome Trust 102770/Z/13/Z
6 · The paper itself

Abstract

Loss-of-function mutations in

Indexed as

Protein MultimerizationUnfolded Protein ResponseAnimalsApoptosis Regulatory ProteinsCells, CulturedElectron Transport Complex IVGenetic Complementation TestHumansMiceMice, KnockoutMitochondrial ProteinsReactive Oxygen SpeciesApopt1 protein, mouseApoptosis Regulatory ProteinsCox4i1 protein, mouseElectron Transport Complex IVMitochondrial ProteinsReactive Oxygen SpeciesAPOPT1‐COA8cytochrome c oxidasemitochondrial encephalopathyproteasome–ubiquitin systemreactive oxygen species

Identifiers

PMID30552096
PMCPMC6328941
OpenAlexW2904513100

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.