ArticleEMBO molecular medicine2019
RGS9-2 rescues dopamine D2 receptor levels and signaling in
Registry-linked trialAbstract read
In one paragraph
Article in EMBO molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05855577 (-Clinical Efficacy of Pharmacological Treatments Targeting Energy Metabolism, Evaluated by Gait Analysis, on Motor Function in Parkinson's Disease Patients), which is not on this map. Cited by 25 papers.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
-Clinical Efficacy of Pharmacological Treatments Targeting Energy Metabolism, Evaluated by Gait Analysis, on Motor Function in Parkinson's Disease Patients
Who cites it
25 citing papers in PubMed.
- Phenotypic characterization of an Atp13a2 knockout rat model of Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Impairment of Group I Metabotropic Glutamate Receptors in the Dorsal Striatum of the R451C-Neuroligin 3 Mouse Model of Autism Spectrum Disorder.Journal of neurochemistry · 2025Article
- Article
- Electrophysiological insights into deep brain stimulation of the network disorder dystonia.Pflugers Archiv : European journal of physiology · 2023Review
- Molecular Mechanisms of Synaptic Plasticity 2.0: Dynamic Changes in Neurons Functions, Physiological and Pathological Process.International journal of molecular sciences · 2023Article
- The muscarinic M4 acetylcholine receptor exacerbates symptoms of movement disorders.Biochemical Society transactions · 2023Review
- Synaptic Dysfunction in Dystonia: Update From Experimental Models.Current neuropharmacology · 2023Review
- Transgenic Mice for the Translational Study of Neuropathic Pain and Dystonia.International journal of molecular sciences · 2022Review
- Electrophysiological characterization of the striatal cholinergic interneurons inDystonia (Lausanne, Switzerland) · 2022Article
- Alpha-Synuclein is Involved in DYT1 Dystonia Striatal Synaptic Dysfunction.Movement disorders : official journal of the Movement Disorder Society · 2022Article
- Biosafety: From a traditional approach to an integrated approach.Frontiers in public health · 2022Article
- Vesicular Acetylcholine Transporter Alters Cholinergic Tone and Synaptic Plasticity in DYT1 Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2021Article
- The critical balance between dopamine D2 receptor and RGS for the sensitive detection of a transient decay in dopamine signal.PLoS computational biology · 2021Article
- Alteration of the cholinergic system and motor deficits in cholinergic neuron-specific Dyt1 knockout mice.Neurobiology of disease · 2021Article
- Investigating the role of striatal dopamine receptor 2 in motor coordination and balance: Insights into the pathogenesis of DYT1 dystonia.Behavioural brain research · 2021Article
- A2A Receptor Dysregulation in Dystonia DYT1 Knock-Out Mice.International journal of molecular sciences · 2021Article
- Effect of Gabapentin in a Neuropathic Pain Model in Mice Overexpressing Human Wild-Type or Human Mutated Torsin A.Life (Basel, Switzerland) · 2021Article
- Is Generalized and Segmental Dystonia Accompanied by Impairments in the Dopaminergic System?Frontiers in neurology · 2021Article
- Regulators of G Protein Signaling in Analgesia and Addiction.Molecular pharmacology · 2020Review
- Dystonia: Sparse Synapses for D2 Receptors in Striatum of a DYT1 Knock-out Mouse Model.International journal of molecular sciences · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Paola BonsiLaboratory of Neurophysiology and Plasticity, IRCCS Fondazione Santa Lucia, Rome, Italy p.bonsi@hsantalucia.it pisani@uniroma2.it.ORCID 0000-0001-5940-9028
Giulia PonterioLaboratory of Neurophysiology and Plasticity, IRCCS Fondazione Santa Lucia, Rome, Italy.
Valentina VanniLaboratory of Neurophysiology and Plasticity, IRCCS Fondazione Santa Lucia, Rome, Italy.
Annalisa TassoneLaboratory of Neurophysiology and Plasticity, IRCCS Fondazione Santa Lucia, Rome, Italy.
Giuseppe SciamannaLaboratory of Neurophysiology and Plasticity, IRCCS Fondazione Santa Lucia, Rome, Italy.
Sara MigliariniUnit of Cell and Developmental Biology, Department of Biology, University of Pisa, Pisa, Italy.
Giuseppina MartellaLaboratory of Neurophysiology and Plasticity, IRCCS Fondazione Santa Lucia, Rome, Italy.
Maria MeringoloLaboratory of Neurophysiology and Plasticity, IRCCS Fondazione Santa Lucia, Rome, Italy.
Benjamin DehayUniversité de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France.ORCID 0000-0003-1723-9045
Evelyne DoudnikoffUniversité de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France.
Venetia ZachariouDepartment of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Rose E GoodchildDepartment of Neurosciences, VIB-KU Leuven Center for Brain and Disease Research, KU Leuven, Leuven, Belgium.ORCID 0000-0002-4524-5728
Nicola B MercuriLaboratory of Neurophysiology and Plasticity, IRCCS Fondazione Santa Lucia, Rome, Italy.
Marcello D'AmelioLaboratory Molecular Neurosciences, IRCCS Fondazione Santa Lucia, Rome, Italy.
Massimo PasqualettiUnit of Cell and Developmental Biology, Department of Biology, University of Pisa, Pisa, Italy.
Erwan BezardUniversité de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France.ORCID 0000-0002-0410-4638
Antonio PisaniLaboratory of Neurophysiology and Plasticity, IRCCS Fondazione Santa Lucia, Rome, Italy p.bonsi@hsantalucia.it pisani@uniroma2.it.ORCID 0000-0002-8432-594X
Funding
REPRESSIVE HISTONE AND DNA METHYLATION IN RODENT DEPRESSION MODELSP50MH096890 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ALLIS, CHARLES DAVID · 2012 to 2021
$20.2MTranscription Factors in Stimulant and Opioid ActionP01DA047233 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Anne Schaefer · 2019 to 2026
$16.5MCellular Mechanisms of Antidepressant Drug Actions in Neuropathic Pain ModelsR01NS086444 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ZACHARIOU, VENETIA · 2014 to 2023
$4.4MTargeting HDAC6 for the treatment of neuropathic painR21NS098264 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ZACHARIOU, VENETIA · 2017 to 2018
$466kNIDA NIH HHS P01 DA047233NIMH NIH HHS P50 MH096890NINDS NIH HHS R01 NS086444NINDS NIH HHS R21 NS098264
Abstract
Dopamine D2 receptor signaling is central for striatal function and movement, while abnormal activity is associated with neurological disorders including the severe early-onset
Indexed as
Signal TransductionAnimalsCorpus StriatumDisease Models, AnimalDystonia Musculorum DeformansGene ExpressionGene Knockdown TechniquesMice, Inbred C57BLMicrofilament ProteinsMolecular ChaperonesNerve Tissue ProteinsNeurabinsReceptors, Dopamine D2RGS ProteinsDRD2 protein, mouseDyt1 protein, mouseMicrofilament ProteinsMolecular ChaperonesNerve Tissue ProteinsNeurabinsReceptors, Dopamine D2regulator of g-protein signaling 9RGS Proteinsbeta‐arrestinlysosomal degradationstriatum
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT05855577ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.