Evidence map›Paper›PMID 30552075›Full record

ArticleNeuroImage. Clinical2019

Cortical thickness atrophy in the transentorhinal cortex in mild cognitive impairment.

Sue Kulason, Daniel J Tward, Timothy Brown, Chelsea S Sicat, Chin-Fu Liu, J Tilak Ratnanather, Laurent Younes, Arnold Bakker, Michela Gallagher, Marilyn Albert and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Amidst an amygdala renaissance in Alzheimer's disease.Brain : a journal of neurology · 2024
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Sue KulasonCenter for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218, USA; Institute for Computational Medicine, The Johns Hopkins University, Baltimore, MD 21218, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA. Electronic address: skulaso1@cis.jhu.edu.
Daniel J TwardCenter for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218, USA; Institute for Computational Medicine, The Johns Hopkins University, Baltimore, MD 21218, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA; Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21218, USA.
Timothy BrownCenter for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218, USA; Institute for Computational Medicine, The Johns Hopkins University, Baltimore, MD 21218, USA.
Chelsea S SicatCenter for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218, USA; Institute for Computational Medicine, The Johns Hopkins University, Baltimore, MD 21218, USA.
Chin-Fu LiuCenter for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218, USA; Institute for Computational Medicine, The Johns Hopkins University, Baltimore, MD 21218, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA.
J Tilak RatnanatherCenter for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218, USA; Institute for Computational Medicine, The Johns Hopkins University, Baltimore, MD 21218, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA.
Laurent YounesCenter for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218, USA; Institute for Computational Medicine, The Johns Hopkins University, Baltimore, MD 21218, USA; Department of Applied Mathematics and Statistics, Johns Hopkins University, Baltimore, MD 21218, USA.
Arnold BakkerDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD 21205, USA.
Michela GallagherDepartment of Psychological and Brain Sciences, Johns Hopkins School of Arts and Sciences, Baltimore, MD 21218, USA.
Marilyn AlbertDepartment of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA.
Michael I MillerCenter for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218, USA; Institute for Computational Medicine, The Johns Hopkins University, Baltimore, MD 21218, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA; Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21218, USA.
Alzheimer's Disease Neuroimaging Initiative
Johns Hopkins University · US

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI MARILYN S. ALBERT · 2020 to 2026
$29.3M
TR&D 4: Algorithms for functional and anatomical brain analysisP41EB015909 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2012 to 2020
$13.1M
PHASE II/III trial for Slowing Progression in Mild Cognitive ImpairmentR01AG048349 · NIA · JOHNS HOPKINS UNIVERSITY · PI ALBERT, MARILYN S., GALLAGHER, MICHELA · 2015 to 2021
$7.6M
Neurodegenerative and Neurodevelopmental Subcortical Shape DiffeomorphometryR01EB020062 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI MILLER, MICHAEL I, MOSTOFSKY, STEWART H · 2016 to 2019
$2.8M
NIA NIH HHS P30 AG066507NIA NIH HHS R01 AG048349NIA NIH HHS U01 AG024904NIBIB NIH HHS P41 EB015909NIBIB NIH HHS R01 EB020062
6 · The paper itself

Abstract

This study examines the atrophy rates of subjects with mild cognitive impairment (MCI) compared to controls in four regions within the medial temporal lobe: the transentorhinal cortex (TEC), entorhinal cortex (ERC), hippocampus, and amygdala. These regions were manually segmented and then corrected for undesirable longitudinal variability via Large Deformation Diffeomorphic Metric Mapping (LDDMM) based longitudinal diffeomorphometry. Diffeomorphometry techniques were used to compare thickness measurements in the TEC with the ERC. There were more significant changes in thickness atrophy rate in the TEC than medial regions of the entorhinal cortex. Volume measures were also calculated for all four regions. Classifiers were constructed using linear discriminant analysis to demonstrate that average thickness and atrophy rate of TEC together was the most discriminating measure compared to the thickness and volume measures in the areas examined, in differentiating MCI from controls. These findings are consistent with autopsy findings demonstrating that initial neuronal changes are found in TEC before spreading more medially in the ERC and to other regions in the medial temporal lobe. These findings suggest that the TEC thickness could serve as a biomarker for Alzheimer's disease in the prodromal phase of the disease.

Indexed as

AgedAmygdalaAtrophyBrainCognitive DysfunctionEntorhinal CortexFemaleHippocampusHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleBraak stagingCortical thicknessEntorhinal cortexLongitudinal analysisMild cognitive impairmentShape analysisTransentorhinal cortex

Identifiers

PMID30552075
PMCPMC6412863
OpenAlexW2903373126

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.