Evidence map›Paper›PMID 30552033›Full record

ArticleDiagnostic microbiology and infectious disease2019

In vitro activity of EDTA and TOL-463 against Neisseria gonorrhoeae.

Evelyn E Nash, Tara C Henning, Cau D Pham, Kevin Pettus, Samera Sharpe, Ellen N Kersh

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostic microbiology and infectious disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Repurposing salicylamide for combating multidrug-resistantAntimicrobial agents and chemotherapy · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Evelyn E NashDivision of Sexually Transmitted Disease Prevention, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, GA, USA. Electronic address: lmq5@cdc.gov.
Tara C HenningDivision of Sexually Transmitted Disease Prevention, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, GA, USA.
Cau D PhamDivision of Sexually Transmitted Disease Prevention, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, GA, USA.
Kevin PettusDivision of Sexually Transmitted Disease Prevention, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, GA, USA.
Samera SharpeDivision of Sexually Transmitted Disease Prevention, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, GA, USA.
Ellen N KershDivision of Sexually Transmitted Disease Prevention, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, GA, USA.
Centers for Disease Control and Prevention · USUnited States Department of Health and Human Services · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

Neisseria gonorrhoeae quickly develops drug resistance. Time-kill curves revealed that EDTA and TOL-463 inhibit growth similar to penicillin, ciprofloxacin, and azithromycin. Furthermore, synergistic and additive antimicrobial interactions occurred when EDTA and TOL-463 were combined with penicillin or azithromycin, respectively, suggesting that further investigations into these unconventional antimicrobials may be advantageous.

Indexed as

Anti-Bacterial AgentsBoric AcidsDrug SynergismEdetic AcidMicrobial Sensitivity TestsNeisseria gonorrhoeaeAnti-Bacterial Agentsboric acidBoric AcidsEdetic AcidAntimicrobial resistanceBoric acidBroth microdilutionEDTANeisseria gonorrhoeae

Identifiers

PMID30552033
PMCPMC6519449
OpenAlexW2899949579

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.