Evidence map›Paper›PMID 30551685›Full record

ArticleMarine drugs2018

Alanine-Scanning Mutagenesis of α-Conotoxin GI Reveals the Residues Crucial for Activity at the Muscle Acetylcholine Receptor.

Jiong Ning, Rui Li, Jie Ren, Dongting Zhangsun, Xiaopeng Zhu, Yong Wu, Sulan Luo

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. An N-Terminally Elongated Peptide From Conus rolani Defines a New Class of Ribbon α-Conotoxins Targeting Muscle nAChRs.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jiong NingKey Laboratory of Tropical Biological Resources, Ministry of Education, Key Lab for Marine Drugs of Haikou, Hainan University, Haikou 570228, Hainan, China. ningjiong2018@163.com.
Rui LiKey Laboratory of Tropical Biological Resources, Ministry of Education, Key Lab for Marine Drugs of Haikou, Hainan University, Haikou 570228, Hainan, China. flychcken@163.com.
Jie RenKey Laboratory of Tropical Biological Resources, Ministry of Education, Key Lab for Marine Drugs of Haikou, Hainan University, Haikou 570228, Hainan, China. hndx2303@163.com.
Dongting ZhangsunKey Laboratory of Tropical Biological Resources, Ministry of Education, Key Lab for Marine Drugs of Haikou, Hainan University, Haikou 570228, Hainan, China. zhangsundt@163.com.
Xiaopeng ZhuKey Laboratory of Tropical Biological Resources, Ministry of Education, Key Lab for Marine Drugs of Haikou, Hainan University, Haikou 570228, Hainan, China. zhuxiaopeng@hainu.edu.cn.
Yong WuKey Laboratory of Tropical Biological Resources, Ministry of Education, Key Lab for Marine Drugs of Haikou, Hainan University, Haikou 570228, Hainan, China. wuyong@hainu.edu.cn.
Sulan LuoKey Laboratory of Tropical Biological Resources, Ministry of Education, Key Lab for Marine Drugs of Haikou, Hainan University, Haikou 570228, Hainan, China. luosulan2003@163.com.ORCID 0000-0002-9358-5970
Hainan University · CN

Funding

Changjiang Scholars and Innovative Research Team in University Grant IRT_15R15Hainan University Youth foundation hdkyx201725Major International Joint Research Project of National Natural Science Foundation of China 81420108028National Natural Science Foundation of China 31760249National Natural Science Foundation of China 81660585
6 · The paper itself

Abstract

Recently, the muscle-type nicotinic acetylcholine receptors (nAChRs) have been pursued as a potential target of several diseases, including myogenic disorders, muscle dystrophies and myasthenia gravis, etc. α-conotoxin GI isolated from

Indexed as

Conus SnailAlanineAmino Acid SequenceAnimalsConotoxinsMolecular Docking SimulationMolecular Dynamics SimulationMuscle, SkeletalMutagenesisNeuromuscular DiseasesNeuromuscular JunctionNicotinic AntagonistsOocytesPatch-Clamp TechniquesReceptors, NicotinicStructure-Activity RelationshipAlanineconotoxin GIConotoxinsNicotinic AntagonistsReceptors, Nicotinicelectrophysiological studymolecular dynamic simulationsmuscle-type nAChRsstructure-activity relationshipα-conotoxin GI

Identifiers

PMID30551685
PMCPMC6315591
OpenAlexW2904870574

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.