Evidence map›Paper›PMID 30551665›Full record

ReviewChildren (Basel, Switzerland)2018

Pediatric Fatty Liver and Obesity: Not Always Justa Matter of Non-Alcoholic Fatty Liver Disease.

Renata Alfani, Edoardo Vassallo, Anna Giulia De Anseris, Lucia Nazzaro, Ida D'Acunzo, Carolina Porfito, Claudia Mandato, Pietro Vajro

Open access · goldAbstract readReview
In one paragraph

Review in Children (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Pediatric nonalcoholic fatty liver disease - a changing diagnostic paradigm.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Renata AlfaniPediatrics Residency Joint Programs, University of Naples Federico II, 80131 Naples, Italy. renata.alfani@gmail.com.
Edoardo VassalloPediatrics Residency Joint Programs, University of Naples Federico II, 80131 Naples, Italy. edoardo.vassa@gmail.com.
Anna Giulia De AnserisClinical Pediatrics Azienda Ospedaliera Universitaria San Giovanni di Dio e Ruggi D'Aragona, 84131 Salerno, Italy. annagiulia.deanseris@gmail.com.
Lucia NazzaroClinical Pediatrics Azienda Ospedaliera Universitaria San Giovanni di Dio e Ruggi D'Aragona, 84131 Salerno, Italy. nazzaroluci@libero.it.
Ida D'AcunzoPediatrics Residency Joint Programs, University of Naples Federico II, 80131 Naples, Italy. ida.dacunzo@gmail.com.
Carolina PorfitoPediatrics Residency Joint Programs, University of Naples Federico II, 80131 Naples, Italy. carolinaporfito@gmail.com.
Claudia MandatoChildren's Hospital Santobono-Pausilipon, Department of Pediatrics, 80129 Naples, Italy. cla.mandato@gmail.com.ORCID 0000-0003-2425-5449
Pietro VajroPediatrics Residency Joint Programs, University of Naples Federico II, 80131 Naples, Italy. pvajro@unisa.it.ORCID 0000-0002-9418-5880
University of Salerno · ITOspedali Riuniti San Giovanni di Dio e Ruggi d'Aragona · ITSantobono Children's Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity-related non-alcoholic fatty liver disease (NAFLD) represents the most common cause of pediatric liver disease due to overweight/obesity large-scale epidemics. In clinical practice, diagnosis is usually based on clinical features, blood tests, and liver imaging. Here, we underline the need to make a correct differential diagnosis for a number of genetic, metabolic, gastrointestinal, nutritional, endocrine, muscular, and systemic disorders, and for iatrogenic/viral/autoimmune hepatitis as well. This is all the more important for patients who are not in the NAFLD classical age range and for those for whom a satisfactory response of liver test abnormalities to weight loss after dietary counseling and physical activity measures cannot be obtained or verified due to poor compliance. A correct diagnosis may be life-saving, as some of these conditions which appear similar to NAFLD have a specific therapy. In this study, the characteristics of the main conditions which require consideration are summarized, and a practical diagnostic algorithm is discussed.

Indexed as

differential diagnosisfatty livergenetic and metabolic disordersNAFLDobesitysystemic disorders

Identifiers

PMID30551665
PMCPMC6306738
OpenAlexW2904649692

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.