Evidence map›Paper›PMID 30551641›Full record

ArticleToxins2018

AbobotulinumtoxinA (Dysport

Malgorzata Field, Andrew Splevins, Philippe Picaut, Marcel van der Schans, Jan Langenberg, Daan Noort, Daniel Snyder, Keith Foster

Erratum issuedOpen access · goldAbstract readComparative Study
In one paragraph

Article in Toxins, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 84 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 4 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 4 syntheses or guidelines pooled it, 145 citations in OpenAlex.

  1. Pooled it
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  13. Observational
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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Malgorzata FieldIpsen Bioinnovation, Abingdon OX14 4RY, UK. gosia.olszowka@gmail.com.
Andrew SplevinsIpsen Bioinnovation, Abingdon OX14 4RY, UK. andrew.splevins@ipsen.com.
Philippe PicautIpsen Pharma, Cambridge, MA 02142, USA. philippe.picaut@ipsen.com.
Marcel van der SchansTNO-CBRN Protection, 2288GJ Rijswijk, The Netherlands. marcel.vanderschans@tno.nl.
Jan LangenbergTNO-CBRN Protection, 2288GJ Rijswijk, The Netherlands. jan.langenberg@tno.nl.
Daan NoortTNO-CBRN Protection, 2288GJ Rijswijk, The Netherlands. daan.noort@tno.nl.
Daniel Snyder
Keith FosterIpsen Bioinnovation, Abingdon OX14 4RY, UK. keith.foster@ipsen.com.
Ipsen (United Kingdom) · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Botulinum neurotoxin type-A (BoNT-A) blocks the release of acetylcholine from peripheral cholinergic nerve terminals and is an important option for the treatment of disorders characterised by excessive cholinergic neuronal activity. Several BoNT-A products are currently marketed, each with unique manufacturing processes, excipients, formulation, and non-interchangeable potency units. Nevertheless, the effects of all the products are mediated by the 150 kDa BoNT-A neurotoxin. We assessed the quantity and light chain (LC) activity of BoNT-A in three commercial BoNT-A products (Dysport

Indexed as

Botulinum Toxins, Type AEnzyme-Linked Immunosorbent AssayHumansMuscle SpasticityNeuromuscular AgentsNeurotoxinsTreatment OutcomeabobotulinumtoxinABotulinum Toxins, Type AincobotulinumtoxinANeuromuscular AgentsNeurotoxinsonabotulinum toxin ABoNTbotulinum toxinDysport®, abobotulinumtoxinAglabellar linesspasticity

Identifiers

PMID30551641
PMCPMC6316182
OpenAlexW2905303601

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.