Evidence map›Paper›PMID 30551605›Full record

ArticleInternational journal of molecular sciences2018

Eukaryotic Initiation Factor 5B (eIF5B) Cooperates with eIF1A and eIF5 to Facilitate uORF2-Mediated Repression of ATF4 Translation.

Joseph A Ross, Kamiko R Bressler, Nehal Thakor

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Editorial: RNA machines.Frontiers in genetics · 2023
    Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. A Retrospective on eIF2A-and Not the Alpha Subunit of eIF2.International journal of molecular sciences · 2020
    Review
  10. Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Joseph A RossDepartment of Chemistry and Biochemistry, University of Lethbridge, 4401 University Drive W, Lethbridge, AB T1K 3M4, Canada. joseph.ross@uleth.ca.ORCID 0000-0002-0432-8383
Kamiko R BresslerDepartment of Chemistry and Biochemistry, University of Lethbridge, 4401 University Drive W, Lethbridge, AB T1K 3M4, Canada. kamiko.bressler@uleth.ca.
Nehal ThakorDepartment of Chemistry and Biochemistry, University of Lethbridge, 4401 University Drive W, Lethbridge, AB T1K 3M4, Canada. nthakor@uleth.ca.
University of Lethbridge · CA

Funding

Campus Alberta Innovates Program and the Alberta Ministry of Economic Development and Trade NACanada Foundation for Innovation-John R. Evans Leaders Fund 35017Natural Sciences and Engineering Research Council of Canada-Discovery Grant RGPIN-2017-05463
6 · The paper itself

Abstract

A variety of cellular stresses lead to global translation attenuation due to phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2), which decreases the availability of the eIF2-GTP-Met-tRNA

Indexed as

Activating Transcription Factor 4Cell LineEndonucleasesEukaryotic Initiation Factor-1Eukaryotic Initiation FactorsEukaryotic Translation Initiation Factor 5AHEK293 CellsHumansPeptide Initiation FactorsPhosphorylationPolyribosomesProtein BiosynthesisRNA-Binding ProteinsRNA-Directed DNA PolymeraseRNA, Small InterferingActivating Transcription Factor 4ATF4 protein, humanEndonucleasesEukaryotic Initiation Factor-1eukaryotic initiation factor-5BEukaryotic Initiation Factorseukaryotic peptide initiation factor-1AEukaryotic Translation Initiation Factor 5AORF2 protein, humanPeptide Initiation FactorsRNA-Binding ProteinsRNA-Directed DNA PolymeraseRNA, Small InterferingActivating Transcription Factor 4 (ATF4)eIF1AeIF2Aeukaryotic initiation factor 2α (eIF2α)eukaryotic initiation factor 5B (eIF5B)upstream open reading frames (uORFs)

Identifiers

PMID30551605
PMCPMC6321046
OpenAlexW2904421021

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.