Evidence map›Paper›PMID 30551603›Full record

ReviewMolecules (Basel, Switzerland)2018

Overview on the Effects of

Giuseppe Tardiolo, Placido Bramanti, Emanuela Mazzon

2 registry-linked trialsOpen access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 148 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
148citing papers in PubMed, 6 pooled it
12.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04562597 phase1 / phase2completednot on this mapstarted 2021, after this paper: background citation

A Pilot Trial to Determine the Effective Dose of N-acetylcysteine for Opioid Reduction in Patients Undergoing Spine Surgery.

TypeinterventionalSponsorMedical University of South CarolinaRan2021 to 2022Enrolled50ConditionsSurgeryArmsDose Response Curve Placebo, Dose Response Curve N-acetylcysteine 50 mg/kg, Dose Response Curve N-acetylcysteine 100 mg/kg, Dose Response Curve N-acetylcysteine 150 mg/kg, Opioid Reduction with Optimal N-acetylcysteine Dose
NCT07391163 nacompletednot on this mapstarted 2024, after this paper: background citation

The Possible Protective Role of N-Acetylcysteine Against Oxaliplatin-Induced Peripheral Neuropathy in Patients With Colorectal Cancer

TypeinterventionalSponsorTanta UniversityRan2024 to 2026Enrolled46ConditionsColorectal CancerArmsPlacebo, N-Acetyl Cysteine, Modified FOLFOX-6 regimen
3 · Its place in the literature

Who cites it

148 citing papers in PubMed, 6 syntheses or guidelines pooled it, 286 citations in OpenAlex.

  1. Pooled it
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  6. Pooled it
  7. Trial
  8. Trial
  9. Article
  10. Redefining the role of the thiol-based agentRSC medicinal chemistry · 2026
    Review
  11. Effect ofBiomedicines · 2026
    Article
  12. Review
  13. Article
  14. Review
  15. Daily intake of antioxidants ameliorates PMFrontiers in nutrition · 2026
    Article
  16. Frontiers in veterinary science · 2026
    Article
  17. Review
  18. Article
  19. Article
  20. Article

88 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Giuseppe TardioloIRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. gstardiolo@gmail.com.
Placido BramantiIRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. bramanti.dino@gmail.com.
Emanuela MazzonIRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. emazzon.irccs@gmail.com.ORCID 0000-0002-5073-717X
Centro Neurolesi Bonino Pulejo · IT

Funding

Ministero della Salute RF-2011-02352582
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AcetylcysteineAnimalsAnti-Inflammatory AgentsAntioxidantsClinical Trials as TopicHumansNeurodegenerative DiseasesSynaptic TransmissionAcetylcysteineAnti-Inflammatory AgentsAntioxidantsAlzheimer’s diseaseglutathione precursorN-acetylcysteineneuropathic painoxidative stressParkinson’s diseasestroke

Identifiers

PMID30551603
PMCPMC6320789
OpenAlexW2904968162

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.