Evidence map›Paper›PMID 30551601›Full record

ArticlePharmaceutics2018

Effect of Penetration Enhancers on Drug Nail Permeability from Cyclodextrin/Poloxamer-Soluble Polypseudorotaxane-Based Nail Lacquers.

Elena Cutrín-Gómez, Soledad Anguiano-Igea, M Begoña Delgado-Charro, José Luis Gómez-Amoza, Francisco J Otero-Espinar

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 31 citations in OpenAlex.

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  14. Clinical Evaluation of a Topical Formulation for the Management of Onychomycosis.The Journal of clinical and aesthetic dermatology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Elena Cutrín-GómezDepartment of Pharmacology, Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela, Santiago de Compostela 15782, Spain. elenacutrin@hotmail.com.
Soledad Anguiano-IgeaDepartment of Pharmacology, Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela, Santiago de Compostela 15782, Spain. s.anguiano.igea@gmail.com.
M Begoña Delgado-CharroDepartment of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK. B.Delgado-Charro@bath.ac.uk.ORCID 0000-0002-2368-5749
José Luis Gómez-AmozaDepartment of Pharmacology, Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela, Santiago de Compostela 15782, Spain. joseluis.gomez.amoza@usc.es.ORCID 0000-0001-7615-6616
Francisco J Otero-EspinarDepartment of Pharmacology, Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela, Santiago de Compostela 15782, Spain. francisco.otero@usc.es.ORCID 0000-0001-9030-2253
Universidade de Santiago de Compostela · ESUniversity of Bath · GB

Funding

Technology Transfer Accelerator of the University of Santiago de Compostela 01/ 2013Xunta de Galicia grant number GRC2013/015 and GPC2017/015 GRC2013/015 and GPC2017/015
6 · The paper itself

Abstract

Nail delivery has interest for local treatment of nail diseases. Nevertheless, the low permeability of drugs in the nail plaque precludes the efficacy of local treatments. The use of penetration enhancers can increase drug permeability and improve the efficacy of the treatment of nail pathologies. In this work, different chemical substances have been evaluated as potential penetration enhancers. With this aim, the effect of different substances such as sodium lauryl sulfate (SLS), polyethylene glycol 300 (PEG 300), carbocysteine,

Indexed as

ciclopirox olamineclobetasol propionatemedicated nail lacquersmethyl-β-cyclodextrinnailnail psoriasisonychomycosispenetration enhancerpoloxamerspolypseudorotaxanestransungual drug delivery

Identifiers

PMID30551601
PMCPMC6321522
OpenAlexW2904996155

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.