Evidence map›Paper›PMID 30551557›Full record

ReviewJournal of fungi (Basel, Switzerland)2018

The Zebrafish as a Model Host for Invasive Fungal Infections.

Emily E Rosowski, Benjamin P Knox, Linda S Archambault, Anna Huttenlocher, Nancy P Keller, Robert T Wheeler, J Muse Davis

Open access · goldAbstract readReview
In one paragraph

Review in Journal of fungi (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 67 citations in OpenAlex.

  1. mBio · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Zebrafish (International journal of molecular sciences · 2024
    Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. AlternativeFrontiers in cellular and infection microbiology · 2024
    Review
  12. Article
  13. bioRxiv : the preprint server for biology · 2023
    Article
  14. Survival Factor A (SvfA) Contributes toJournal of fungi (Basel, Switzerland) · 2023
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Novel Insights intoJournal of fungi (Basel, Switzerland) · 2022
    Review
  20. Current Models to Study theFrontiers in fungal biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Emily E RosowskiDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53716, USA. erosowski@wisc.edu.
Benjamin P KnoxDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53716, USA. bpknox@wisc.edu.
Linda S ArchambaultDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA. linda.archambault@maine.edu.ORCID 0000-0003-0205-9463
Anna HuttenlocherDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53716, USA. huttenlocher@wisc.edu.
Nancy P KellerDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53716, USA. npkeller@wisc.edu.ORCID 0000-0002-4386-9473
Robert T WheelerDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA. robert.wheeler1@maine.edu.ORCID 0000-0003-3223-7021
J Muse DavisStead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. james-davis@uiowa.edu.
University of Wisconsin–Madison · USUniversity of Maine · USUniversity of Iowa · US

Funding

Mechanisms of an Aspergillus fumigatus virulence mutantR01AI065728 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KELLER, NANCY P · 2006 to 2017
$3.6M
Fungal and Host Factors in Initiation of Cryptococcal PersistenceK08AI132720 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI DAVIS, JAMES MUSE · 2018 to 2022
$949k
Intravital study of innate immunity to mucosal candidiasisR15AI133415 · NIAID · UNIVERSITY OF MAINE ORONO · PI WHEELER, ROBERT T. · 2018 to 2018
$415k
Burroughs Wellcome Fund PATHNational Institutes of Health 5R01AI065728-10National Institutes of Health K08AI132720National Institutes of Health R15AI133415NIAID NIH HHS K08 AI132720NIAID NIH HHS R01 AI065728NIAID NIH HHS R15 AI133415U.S. Department of Agriculture ME-021821
6 · The paper itself

Abstract

The zebrafish has become a widely accepted model host for studies of infectious disease, including fungal infections. The species is genetically tractable, and the larvae are transparent and amenable to prolonged in vivo imaging and small molecule screening. The aim of this review is to provide a thorough introduction into the published studies of fungal infection in the zebrafish and the specific ways in which this model has benefited the field. In doing so, we hope to provide potential new zebrafish researchers with a snapshot of the current toolbox and prior results, while illustrating how the model has been used well and where the unfulfilled potential of this model can be found.

Indexed as

AspergillusCandidaCryptococcushost–pathogen interactionsinnate immunitymacrophagemucormycosisneutrophilTalaromyceszebrafish

Identifiers

PMID30551557
PMCPMC6308935
OpenAlexW2904631392

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.