SynthesisBrain : a journal of neurology2019
Network localization of heterogeneous neuroimaging findings.
Synthesis in Brain : a journal of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed, 7 syntheses or guidelines pooled it, 144 citations in OpenAlex.
- Heterogeneous brain alterations in treatment-resistant depression converge on common control networks.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Pooled it
- Mapping the multi-scale landscape of vascular cognitive impairment: from structural atrophy networks to cellular and neurochemical substrates.Journal of neurology · 2026Pooled it
- Network localization of regional intrinsic neural activity alterations in migraine and their neurochemical correlates.Frontiers in neurology · 2026Pooled it
- Associations between Neuroimaging Measures and Cognitive Performance in Children, Adolescents, and Youth Living With HIV-a Systematic Review.Current HIV/AIDS reports · 2025Pooled it
- Heterogeneous Brain Abnormalities in Schizophrenia Converge on a Common Network Associated With Symptom Remission.Schizophrenia bulletin · 2024Pooled it
- A transdiagnostic network for psychiatric illness derived from atrophy and lesions.Nature human behaviour · 2023Pooled it
- Activation network mapping for integration of heterogeneous fMRI findings.Nature human behaviour · 2022Pooled it
- Linking Personalized Brain Atrophy to Schizophrenia Network and Treatment Response.Schizophrenia bulletin · 2023Trial
- Heterogeneous neuroimaging findings in obsessive-compulsive disorder converge to a common brain network using coordinate network mapping.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Brain Structural and Functional Alteration Network Localization of Visual Hallucinations.Schizophrenia bulletin · 2026Article
- Brain network representations of placebo analgesia.Psychological medicine · 2026Article
- Investigating the methodological foundation of lesion network mapping.Nature neuroscience · 2026Article
- Multimodal network localization of brain abnormalities and neuromodulation target identification in obsessive-compulsive disorder.Scientific reports · 2026Article
- Brain network localization of anhedonia.Translational psychiatry · 2026Article
- Network localization of brain functional effects of ketamine treatment for major depression.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- Network Localization of Functional Brain Changes Associated With Ketamine's Therapeutic Effects in Depression.Biological psychiatry · 2026Article
- Distinct antidepressant therapies act on a common brain network.Nature communications · 2026Article
- Convergent functional networks of intrinsic activity alterations in temporal lobe epilepsy and their molecular correlates.Frontiers in molecular neuroscience · 2026Article
- Network localization of gray matter alterations in chronic smokers using the normative functional connectome.Frontiers in public health · 2026Article
- Network localization of functional and structural correlates of apathy in Parkinson's disease.Frontiers in systems neuroscience · 2026Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Studies of the same disease often implicate different brain regions, contributing to a perceived reproducibility crisis in neuroimaging. Here, we leverage the normative human brain connectome to test whether seemingly heterogeneous neuroimaging findings localize to connected brain networks. We use neurodegenerative disease, and specifically Alzheimer's disease, as our example as it is one of the diseases that has been studied the most using neuroimaging. First, we show that neuroimaging findings in Alzheimer's disease occur in different brain regions across different studies but localize to the same functionally connected brain network. Second, we show that neuroimaging findings across different neurodegenerative diseases (Alzheimer's disease, frontotemporal dementia, corticobasal syndrome, and progressive non-fluent aphasia) localize to different disease-specific brain networks. Finally, we show that neuroimaging findings for a specific symptom within a disease (delusions in Alzheimer's disease) localize to a symptom-specific brain network. Our results suggest that neuroimaging studies that appear poorly reproducible may identify different regions within the same connected brain network. Human connectome data can be used to link heterogeneous neuroimaging findings to common neuroanatomy, improving localization of neuropsychiatric diseases and symptoms.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.