ArticleAmerican journal of epidemiology2019
Potential Effects on Mortality of Replacing Sedentary Time With Short Sedentary Bouts or Physical Activity: A National Cohort Study.
Article in American journal of epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Synthesis and Validity of Accelerometer Devices and Methods Used in Epidemiological Studies of Physical Activity Bout Duration and Health Outcomes: A Systematic Review.Sports medicine - open · 2026Pooled it
- Effectiveness of workplace interventions with digital elements to reduce sedentary behaviours in office employees: a systematic review and meta-analysis.The international journal of behavioral nutrition and physical activity · 2024Pooled it
- A systematic review and meta-analysis of the effect of treadmill desks on energy expenditure, sitting time and cardiometabolic health in adults.BMC public health · 2021Pooled it
- Effects of physically active lessons and active breaks on cognitive performance and health indicators in elementary school children: a cluster randomized trial.The international journal of behavioral nutrition and physical activity · 2025Trial
- Testing the Recruitment Frequency, Implementation Fidelity, and Feasibility of Outcomes of the Heart Failure Activity Coach Study (HEALTHY): Pilot Randomized Controlled Trial.JMIR formative research · 2025Trial
- Associations of accelerometer-based sedentary bouts with adiposity markers among German adults - results from a cross-sectional study.BMC public health · 2023Trial
- Responsiveness of electromyographically assessed skeletal muscle inactivity: methodological exploration and implications for health benefits.Scientific reports · 2022Trial
- Exploring habit strength, reward value, and context stability of sedentary activities in older adults: An ecological momentary assessment study.Applied psychology. Health and well-being · 2026Article
- Bidirectional associations of recreational sedentary screen time and 24-h behaviors: a dynamic cross-sectional multilevel model analysis.Journal of activity, sedentary and sleep behaviors · 2026Article
- Effects of a joint outdoor exercise program for dog owners and dogs on physical activity, sedentary time and sleep-related behaviors.PloS one · 2026Article
- Reallocation of time between accelerometer-derived movement behaviors, genetic susceptibility, and risk of incident dementia, mortality, and premature death: a longitudinal cohort study.The international journal of behavioral nutrition and physical activity · 2025Article
- Do cardiovascular disease patients return to pre-lockdown sedentary levels? A prospective cohort study.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2025Article
- Sitting less and moving more: the impact of physical activity on mortality in the population of Spain.BMC public health · 2024Article
- Association between profiles of accelerometer-measured daily movement behaviour and mortality risk: a prospective cohort study of British older adults.BMJ open sport & exercise medicine · 2024Article
- Replacing of sedentary behavior with physical activity and the risk of mortality in people with prediabetes and diabetes: a prospective cohort study.The international journal of behavioral nutrition and physical activity · 2023Article
- Objective Measurement of Physical Activity and Sedentary Behavior in Patients with Chronic Obstructive Pulmonary Disease: Points to Keep in Mind during Evaluations.Journal of clinical medicine · 2023Review
- The association between daily sedentary and active bout frequency with mortality risk in older men using accelerometry.Journal of the American Geriatrics Society · 2023Article
- Substituting device-measured sedentary time with alternative 24-hour movement behaviours: compositional associations with adiposity and cardiometabolic risk in the ORISCAV-LUX 2 study.Diabetology & metabolic syndrome · 2023Article
- Associations of sleeping, sedentary and physical activity with phenotypic age acceleration: a cross-sectional isotemporal substitution model.BMC geriatrics · 2023Article
- Sleep Should Be Focused on When Analyzing Physical Activity in Hospitalized Older Adults after Trunk and Lower Extremity Fractures-A Pilot Study.Healthcare (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Little is known concerning the type of activity that should be substituted for sedentary time and its potentially most hazardous form (prolonged sedentary bouts) to impart health benefit. We used isotemporal substitution techniques to examine whether 1) replacing total sedentary time with light-intensity or moderate to vigorous physical activity (LIPA or MVPA) or 2) replacing prolonged sedentary bouts with shorter sedentary bouts is associated with reductions in all-cause mortality risk. Participants (n = 7,999) from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, a national cohort of US adults aged ≥45 years, were studied. Sedentary time was measured by accelerometry between 2009 and 2013. There was a beneficial association with mortality risk for replacing total sedentary time with both LIPA (per 30 minutes, hazard ratio (HR) = 0.83; 95% confidence interval (CI): 0.80, 0.87) and MVPA (per 30 minutes, HR = 0.65; 95% CI: 0.50, 0.85). Similarly, there was a beneficial association for replacing prolonged sedentary-bout time with LIPA and MVPA but not for replacement with shorter sedentary bouts (per 30 minutes, HR = 1.00; 95% CI: 0.96, 1.03). These findings suggest short sedentary bouts still carry mortality risk and are not a healthful alternative to prolonged sedentary bouts. Instead, physical activity of any intensity is needed to mitigate the mortality risks incurred by sedentary time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.