ArticleNeurobiology of aging2019
Striking reduction in neurons and glial cells in anterior thalamic nuclei of older patients with Down syndrome.
Article in Neurobiology of aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Structural MRI across lifespan reveals differential thalamic trajectories in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Percheron syndrome with memory impairment as chief manifestation: A case report.World journal of clinical cases · 2025Article
- Glial Cells in Spinal Muscular Atrophy: Speculations on Non-Cell-Autonomous Mechanisms and Therapeutic Implications.Neurology international · 2025Review
- Resilience of Neural Cellularity to the Influence of Low Educational Level.Brain sciences · 2023Article
- Thalamic nuclei changes in early and late onset Alzheimer's disease.Current research in neurobiology · 2023Article
- The anterior thalamic nuclei: core components of a tripartite episodic memory system.Nature reviews. Neuroscience · 2022Review
- The innate immune system stimulating cytokine GM-CSF improves learning/memory and interneuron and astrocyte brain pathology in Dp16 Down syndrome mice and improves learning/memory in wild-type mice.Neurobiology of disease · 2022Article
- Neurosymbolic Systems of Perception and Cognition: The Role of Attention.Frontiers in psychology · 2022Article
- The anterior thalamic nuclei and cognition: A role beyond space?Neuroscience and biobehavioral reviews · 2021Review
- The flavonoid 7,8-DHF fosters prenatal brain proliferation potency in a mouse model of Down syndrome.Scientific reports · 2021Article
- Time to put the mammillothalamic pathway into context.Neuroscience and biobehavioral reviews · 2021Review
- Mammillothalamic Disconnection Alters Hippocampocortical Oscillatory Activity and Microstructure: Implications for Diencephalic Amnesia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- The Cognitive Thalamus as a Gateway to Mental Representations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Review
- Article
- Cognitive markers for the distinction between asymptomatic and prodromal Alzheimer's disease in Down syndrome: Correlations with volumetric brain changes.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Abnormal degree centrality and functional connectivity in Down syndrome: A resting-state fMRI study.International journal of clinical and health psychology : IJCHPArticle
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The anterior thalamic nuclei are important for spatial and episodic memory, however, surprisingly little is known about the status of these nuclei in neurological conditions that present with memory impairments, such as Down syndrome. We quantified neurons and glial cells in the anterior thalamic nuclei of four older patients with Down syndrome. There was a striking reduction in the volume of the anterior thalamic nuclei and this appeared to reflect the loss of approximately 70% of neurons. The number of glial cells was also reduced but to a lesser degree than neurons. The anterior thalamic nuclei appear to be particularly sensitive to effects of aging in Down syndrome and the pathology in this region likely contributes to the memory impairments observed. These findings reaffirm the importance of examining the status of the anterior thalamic nuclei in conditions where memory impairments have been principally assigned to pathology in the medial temporal lobe.
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Registered trials
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