ReviewNeuroscience and biobehavioral reviews2019
Challenges and demand for modeling disorders of consciousness following traumatic brain injury.
Review in Neuroscience and biobehavioral reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Innovative Biomaterials for Modulating Neuroinflammation and Promoting Repair After Traumatic Brain Injury.Pharmaceutics · 2026Review
- The Dipeptidyl Peptidase-4 Inhibitor Saxagliptin as a Candidate Treatment for Disorders of Consciousness: A Deep Learning and Retrospective Clinical Analysis.Neurocritical care · 2025Article
- Unravelling Secondary Brain Injury: Insights from a Human-Sized Porcine Model of Acute Subdural Haematoma.Cells · 2024Article
- Neuropathological mRNA Expression Changes after Single Mild Traumatic Brain Injury in Pigs.Biomedicines · 2024Article
- Porcine Models of Neurotrauma and Neurological Disorders.Biomedicines · 2024Article
- Disorders of nomenclature.CNS neuroscience & therapeutics · 2024Article
- Review
- Multimodal Neuromonitoring and Neurocritical Care in Swine to Enhance Translational Relevance in Brain Trauma Research.Biomedicines · 2023Article
- Functional networks in prolonged disorders of consciousness.Frontiers in neuroscience · 2023Review
- Cognitive-motor dissociation and time to functional recovery in patients with acute brain injury in the USA: a prospective observational cohort study.The Lancet. Neurology · 2022Observational
- Research Needs for Prognostic Modeling and Trajectory Analysis in Patients with Disorders of Consciousness.Neurocritical care · 2021Article
- Mechanisms Underlying Disorders of Consciousness: Bridging Gaps to Move Toward an Integrated Translational Science.Neurocritical care · 2021Article
- The Timecourse of Electrophysiological Brain-Heart Interaction in DoC Patients.Brain sciences · 2021Article
- Landing a Successful R or K Grant: a Young Investigator's Journey.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2021Article
- Mechanosensation in traumatic brain injury.Neurobiology of disease · 2021Review
- Diagnostic Developments in Differentiating Unresponsive Wakefulness Syndrome and the Minimally Conscious State.Frontiers in neurology · 2021Review
- Relationships between injury kinematics, neurological recovery, and pathology following concussion.Brain communications · 2021Article
- Differentiating Responders and Non-responders to rTMS Treatment for Disorder of Consciousness Using EEG After-Effects.Frontiers in neurology · 2020Article
- Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Following severe traumatic brain injury (TBI), many patients experience coma - an unresponsive state lacking wakefulness or awareness. Coma rarely lasts more than two weeks, and emergence involves passing through a state of wakefulness without awareness of self or environment. Patients that linger in these Disorders of Consciousness (DoC) undergo clinical assessments of awareness for diagnosis into Unresponsive Wakefulness Syndrome (no awareness, also called vegetative state) or Minimally Conscious State (periodic increases in awareness). These diagnoses are notoriously inaccurate, offering little prognostic value. Recovery of awareness is unpredictable, returning within weeks, years, or never. This leaves patients' families with difficult decisions and little information on which to base them. Clinical studies have made significant advancements, but remain encumbered by high variability, limited data output, and a lack of necessary controls. Herein we discuss the clear and present need to establish a preclinical model of TBI-induced DoC, the significant challenges involved, and how such a model can be applied to support DoC research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.