Observational studyThe Journal of clinical psychiatry2018
Toward Prevention of Mild Cognitive Impairment in Older Adults With Depression: An Observational Study of Potentially Modifiable Risk Factors.
Observational study in The Journal of clinical psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Risk factors of mild behavioral impairment: a systematic review.Frontiers in psychology · 2025Pooled it
- Burden of Illness in People with Alzheimer's Disease: A Systematic Review of Epidemiology, Comorbidities and Mortality.The journal of prevention of Alzheimer's disease · 2024Pooled it
- A Pilot Study of Interactive-Video Games in People with Mild Cognitive Impairment.International journal of environmental research and public health · 2022Trial
- The effects of six months Persicaria minor extract supplement among older adults with mild cognitive impairment: a double-blinded, randomized, and placebo-controlled trial.BMC complementary medicine and therapies · 2020Trial
- Predictive model for mild cognitive impairment in older Chinese adults with depression.Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2025Article
- Relationship Between Depression and Neurodegeneration: Risk Factor, Prodrome, Consequence, or Something Else? A Scoping Review.Biomedicines · 2025Review
- The mediating role of daily living ability and sleep in depression and cognitive function based on a structural equation model.BMC geriatrics · 2025Article
- Risk Factors Influencing Cognitive Function in Elderly Patients With Late-Life Depression: A Scoping Review.Brain and behavior · 2025Article
- Self-reported hearing loss is associated with faster cognitive and functional decline but not diagnostic conversion in the ADNI cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Risk scores of incident mild cognitive impairment in a Beijing community-based older cohort.Frontiers in aging neuroscience · 2022Article
- The efficacy of mindfulness-based cognitive therapy to improve depression symptoms and quality of life in individuals with memory difficulties and caregivers: A short report.Alzheimer's & dementia (New York, N. Y.) · 2022Article
- Associations Between Total Sleep Duration and Cognitive Function Among Middle-Aged and Older Chinese Adults: Does Midday Napping Have an Effect on It?International journal of general medicine · 2022Article
- Alzheimer's Disease Prevention Health Coaching.The journal of prevention of Alzheimer's disease · 2022Article
- Clinical Neuropsychological Evaluation in Older Adults With Major Depressive Disorder.Current psychiatry reports · 2021Review
- Age-Related Hearing Loss, Late-Life Depression, and Risk for Incident Dementia in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Increase in Number of Depression Symptoms Over Time is Related to Worse Cognitive Outcomes in Older Adults With Type 2 Diabetes.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2021Article
- Intensive control of hypertension and risk of Alzheimer's dementia in older adults with depression.International journal of geriatric psychiatry · 2020Article
- The relationship between DMFT index and cognitive impairment: A descriptive cross-sectional study.Journal of family medicine and primary care · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveLate-life depression has been associated with increased risk of mild cognitive impairment (MCI) and dementia. Predictors of increased risk are incompletely understood. Identification of potentially modifiable risk factors could facilitate prevention of MCI and dementia. This study aimed to determine which clinical characteristics are associated with increased risk of MCI among older adults with depression and normal cognition at baseline.
methodsData from the National Alzheimer's Coordinating Center dataset were used. Study participants who attended a participating Alzheimer's Disease Center from September 2005 through September 2017 with normal cognition and a history of clinically defined depression (broadly based on DSM criteria) were followed until first diagnosis of MCI (or dementia when MCI was not diagnosed).
resultsA total of 2,655 study participants were followed for a median duration of 41.8 months. Of these, 586 (22.1%) developed either MCI (n = 509, 19.2%) or dementia (n = 77, 2.9%). In survival analyses, cognitive decline was associated with age, sex, education, baseline cognition, and several potentially modifiable risk factors including vascular risk factors, hearing impairment, vitamin B₁₂ deficiency, active depression within the last 2 years, and increased severity of depression. In an adjusted survival analysis, the only variables that remained significantly associated with development of MCI or dementia were female sex (HR = 0.72; 95% CI, 0.59-0.88), higher education (HR = 0.96; 95% CI, 0.93-0.99), and higher baseline cognition (HR = 0.87; 95% CI, 0.82-0.93), which were associated with reduced risk, and older age (HR = 1.07; 95% CI, 1.05-1.08), active depression within the last 2 years (HR = 1.41; 95% CI, 1.15-1.74), and increased severity of depression (HR = 1.05; 95% CI, 1.02-1.09), which were associated with increased risk.
conclusionsDevelopment of MCI is associated with several potentially modifiable risk factors in older adults with depression. Future studies should determine whether active management of risk factors could reduce incidence of MCI in this vulnerable population.
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