ArticleNMR in biomedicine2019
Collagen proton fraction from ultrashort echo time magnetization transfer (UTE-MT) MRI modelling correlates significantly with cortical bone porosity measured with micro-computed tomography (μCT).
Article in NMR in biomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 47 citations in OpenAlex.
- Bone organic matrix quality indices associate with fragility fracture occurrence independently of bone mineral density values.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Direct MRI of collagen.eLife · 2026Article
- Accelerated ultrashort echo time quantitative magnetization transfer (UTE-qMT) imaging of macromolecular fraction (MMF) in cortical bone based on a self-attention convolutional neural network.Magnetic resonance imaging · 2025Article
- UTE MRI technical developments and applications in osteoporosis: a review.Frontiers in endocrinology · 2025Review
- Are Collagen Protons Visible with the Zero Echo Time (ZTE) Magnetic Resonance Imaging Sequence: A DBioengineering (Basel, Switzerland) · 2024Article
- Towards assessing and improving the reliability of ultrashort echo time quantitative magnetization transfer (UTE-qMT) MRI of cortical bone: In silico and ex vivo study.Magma (New York, N.Y.) · 2024Article
- Significant age-related differences between lower leg muscles of older and younger female subjects detected by ultrashort echo time magnetization transfer modeling.NMR in biomedicine · 2024Article
- Ultrashort echo time MRI detects significantly lower collagen but higher pore water in the tibial cortex of female patients with osteopenia and osteoporosis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Assessment of Osteoporosis at the Lumbar Spine Using Ultrashort Echo Time Magnetization Transfer (UTE-MT) MRI.Journal of magnetic resonance imaging : JMRI · 2024Article
- Ultrasound attenuation of cortical bone correlates with biomechanical, microstructural, and compositional properties.European radiology experimental · 2024Article
- Bone Biomarkers Based on Magnetic Resonance Imaging.Seminars in musculoskeletal radiology · 2024Review
- Achilles tendon and enthesis assessment using ultrashort echo time magnetic resonance imaging (UTE-MRI) T1 and magnetization transfer (MT) modeling in psoriatic arthritis.NMR in biomedicine · 2024Article
- Micron-resolution Imaging of Cortical Bone under 14 T Ultrahigh Magnetic Field.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Article
- Robust Assessment of Macromolecular Fraction (MMF) in Muscle with Differing Fat Fraction Using Ultrashort Echo Time (UTE) Magnetization Transfer Modeling with Measured T1.Diagnostics (Basel, Switzerland) · 2023Article
- MRI-based porosity index (PI) and suppression ratio (SR) in the tibial cortex show significant differences between normal, osteopenic, and osteoporotic female subjects.Frontiers in endocrinology · 2023Article
- Making the invisible visible-ultrashort echo time magnetic resonance imaging: Technical developments and applications.Applied physics reviews · 2022Review
- Correlation between the elastic modulus of anterior cruciate ligament (ACL) and quantitative ultrashort echo time (UTE) magnetic resonance imaging.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Ultrashort Echo Time Magnetic Resonance Imaging Techniques: Met and Unmet Needs in Musculoskeletal Imaging.Journal of magnetic resonance imaging : JMRI · 2022Review
- Lower Macromolecular Content in Tendons of Female Patients with Osteoporosis versus Patients with Osteopenia Detected by Ultrashort Echo Time (UTE) MRI.Diagnostics (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Intracortical bone porosity is a key microstructural parameter that determines bone mechanical properties. While clinical MRI visualizes the cortical bone with a signal void, ultrashort echo time (UTE) MRI can acquire high signal from cortical bone, thus enabling quantitative assessments. Magnetization transfer (MT) imaging combined with UTE-MRI can indirectly assess protons in the bone collagenous matrix, which are inversely related to porosity. This study aimed to examine UTE-MT MRI techniques to evaluate intracortical bone porosity. Eighteen human cortical bone specimens from the tibial and fibular midshafts were scanned using UTE-MT sequences on a clinical 3 T MRI scanner and on a high-resolution micro-computed tomography (μCT) scanner. A series of MT pulse saturation powers (500°, 1000°, 1500°) and frequency offsets (2, 5, 10, 20, 50 kHz) were used to measure the macromolecular fraction (MMF) and macromolecular T
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.