ReviewThe European journal of neuroscience2020
Circadian disruption and human health: A bidirectional relationship.
Review in The European journal of neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
76 citing papers in PubMed, 2 syntheses or guidelines pooled it, 151 citations in OpenAlex.
- Social and circadian rhythm dysregulation and suicide: A systematic review and meta-analysis.Neuroscience and biobehavioral reviews · 2024Pooled it
- Preventing and treating childhood obesity by sleeping better: a systematic review.Frontiers in endocrinology · 2024Pooled it
- Small-Molecule Kinase Inhibitors Modulating Circadian Rhythms.Medicinal research reviews · 2026Review
- Exercise and Circadian Rhythm Regulation: Mechanisms, Resilience, and Therapeutic Potential for Neurological Diseases.CNS neuroscience & therapeutics · 2026Review
- Sleep Duration and Epilepsy Risk: Mendelian Randomization and Functional Validation of CACNA1A rs2228130-Related Inhibitory Synaptic Dysfunction.Neuromolecular medicine · 2026Article
- Associations between multiple metabolic indices and circadian syndrome: a cross-sectional study with mediation analysis of the C-reactive protein triglyceride glucose index.Hormones (Athens, Greece) · 2026Article
- Internal desynchrony of the hepatic circadian system with dissociated systemic rhythms in middle-aged mice under social jet lag-like conditions.Scientific reports · 2026Article
- "Phenotyping obstructive sleep apnea: a pathway to precision medicine".Sleep & breathing = Schlaf & Atmung · 2026Review
- Circadian Health Training in Latin America: Translating Chronobiology into Clinical Practice.Sleep science (Sao Paulo, Brazil) · 2026Article
- The association between night shift work and elevated risk of smoking use among ride-hailing drivers: findings from a cross-sectional study.Frontiers in public health · 2026Article
- Circadian Control of Lipid Metabolism.Advances in experimental medicine and biology · 2026Review
- DCPR: a deep learning framework for circadian phase reconstruction.BMC bioinformatics · 2025Article
- Circadian clock genes and insomnia: molecular mechanisms and therapeutic implications.Annals of medicine · 2025Review
- Article
- Circadian nutrition and obesity: timing as a nutritional strategy.Journal of health, population, and nutrition · 2025Review
- Cortisol Detection Methods and the Hormone's Role in Evaluating Circadian Rhythm Disruption.International journal of molecular sciences · 2025Review
- Endothelial metabolic zonation in the vascular network: a spatiotemporal blueprint for angiogenesis.American journal of physiology. Heart and circulatory physiology · 2025Review
- More variable circadian rhythms in epilepsy captured by long-term heart rate recordings from wearable sensors.Epilepsia · 2025Article
- Spatiotemporal Control Over Circadian Rhythms With Light.Medicinal research reviews · 2025Review
- Circadian Rhythms, Immune Regulation, and the Risk for Sepsis: Circadian Rhythms and Neonatal Care.Clinics in perinatology · 2025Review
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Circadian rhythm disorders have been classically associated with disorders of abnormal timing of the sleep-wake cycle, however circadian dysfunction can play a role in a wide range of pathology, ranging from the increased risk for cardiometabolic disease and malignancy in shift workers, prompting the need for a new field focused on the larger concept of circadian medicine. The relationship between circadian disruption and human health is bidirectional, with changes in circadian amplitude often preceding the classical symptoms of neurodegenerative disorders. As our understanding of the importance of circadian dysfunction in disease grows, we need to develop better clinical techniques for identifying circadian rhythms and also develop circadian based strategies for disease management. Overall this review highlights the need to bring the concept of time to all aspects of medicine, emphasizing circadian medicine as a prime example of both personalized and precision medicine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.