ArticleNeurogastroenterology and motility2019
Multiple psychological factors predict abdominal pain severity in children with irritable bowel syndrome.
Article in Neurogastroenterology and motility, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The trial behind it
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Who cites it
36 citing papers in PubMed, 46 citations in OpenAlex.
- The effect of anti-nausea wristbands and STW-5 in children suffering from dyspepsia - a randomized double-blind placebo-controlled pilot-study.Klinische Padiatrie · 2026Trial
- The effect of self-management online modules plus nurse-led support on pain and quality of life among young adults with irritable bowel syndrome: A randomized controlled trial.International journal of nursing studies · 2022Trial
- Mediation of outcomes for cognitive behavioral therapy targeted to parents of children with Functional Abdominal Pain Disorders.Journal of psychosomatic research · 2021Trial
- Somatization in patients with predominant diarrhoea irritable bowel syndrome: the role of the intestinal barrier function and integrity.BMC gastroenterology · 2021Trial
- The Mediating Role of Pain Catastrophizing in Functioning and Mental Health for Youth With Pain-predominant Disorders of Gut-Brain Interaction.Journal of clinical gastroenterology · 2026Article
- Menstrual-Associated Gastrointestinal Symptoms and Their Impact on IBS Diagnosis in Adolescents.Neurogastroenterology and motility · 2026Article
- Psychological Traits and Social Factors Associated with Irritable Bowel Syndrome in Children.Children (Basel, Switzerland) · 2026Article
- Overlap of Structural Gastrointestinal Disorders in Children With Disorders of Gut-Brain Interaction.Neurogastroenterology and motility · 2026Review
- Risk Factors for Transition of Care in Disorders of Gut-Brain Interaction: A Narrative Review and Expert Opinion.Children (Basel, Switzerland) · 2025Review
- Repeat round of auricular percutaneous electrical nerve field stimulation for pediatric disorders of gut brain interaction.Journal of pediatric gastroenterology and nutrition · 2025Article
- Carbidopa: beyond Parkinson's disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Review
- Anxiety disorders presenting as gastrointestinal symptoms in children - a scoping review.Clinical and experimental pediatrics · 2025Article
- Anxiety and Depression in Children with Irritable Bowel Syndrome-A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- Psychological determinants of irritable bowel syndrome and its impact on quality of life: a machine learning approaches.Gastroenterology and hepatology from bed to bench · 2025Article
- Understanding functional abdominal pain disorders among children: a multidisciplinary expert consensus statement.Frontiers in pediatrics · 2025Review
- Parental Factors Associated to Functional Abdominal Pain Disorders in the Pediatric Age Group: A Case-Control Study.Advanced biomedical research · 2025Article
- A Scoping Review of Sleep Disturbances in Children and Adolescents with Abdominal Pain Disorders.Pediatric health, medicine and therapeutics · 2025Review
- Pediatric to adult transition care in neurogastroenterology and motility: A position paper from the American Neurogastroenterology and Motility Society and European Society of Neurogastroenterology and Motility.Neurogastroenterology and motility · 2024Review
- Italian guidelines for the management of irritable bowel syndrome in children and adolescents : Joint Consensus from the Italian Societies of: Gastroenterology, Hepatology and Pediatric Nutrition (SIGENP), Pediatrics (SIP), Gastroenterology and Endoscopy (SIGE) and Neurogastroenterology and Motility (SINGEM).Italian journal of pediatrics · 2024Review
- Psychological distress and coping efficacy in children with disorders of gut-brain interaction.Neurogastroenterology and motility · 2024Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundAnxiety and depression are implicated as contributors to abdominal pain in pediatric irritable bowel syndrome (IBS) but is unclear if this pain is associated with other psychological factors. The study objective was to test if the impact of anxiety or depression on IBS symptom severity is mediated by somatization and/or pain catastrophizing.
methodsWe utilized baseline data from local pediatric IBS clinical studies. Through mediation analysis, we assessed whether somatization or pain catastrophizing mediated (either independently or combined) the separate relationships of anxiety or depression with IBS abdominal pain severity. KEY
resultsWe analyzed 261 participants. All psychological factors were positively correlated with one another and IBS abdominal pain severity. The association of anxiety with IBS abdominal pain was mediated by both somatization and pain catastrophizing in individual analyses (each mediated standardized coefficient [β] 0.11, CI 0.05-0.18) and in multiple analysis (mediated standardized β 0.18, CI 0.09-0.27). The association of depression with IBS abdominal pain was also mediated by somatization (mediated standardized β 0.08, CI0.02-0.14) and pain catastrophizing (mediated standardized β 0.06, CI 0.01-0.11) in individual analyses and in multiple analysis (mediated standardized β 0.19, CI 0.04-0.19). CONCLUSIONS AND INFERENCES: Somatization and pain catastrophizing mediate the relationships between anxiety/depression and IBS abdominal pain severity. These findings suggest that somatization and pain catastrophizing may be better treatment targets than anxiety and depression. Clinicians should assess these psychological factors in pediatric IBS patients and refer for intervention to improve outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.