ArticleHead & neck2019
Association between comorbidity and survival in head and neck cancer: Results from Head and Neck 5000.
Article in Head & neck, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A comprehensive examination of mental health in patients with head and neck cancer: systematic review and meta-analysis.JNCI cancer spectrum · 2024Pooled it
- Biologically adaptive radiotherapy for oropharyngeal Cancer (BARitOne): An R-IDEAL stage 2a-2b technical optimisation, feasibility, and safety study - Study protocol.Clinical and translational radiation oncology · 2026Article
- Evaluation of the Naples Prognostic Score in Patients with Head and Neck Squamous Cell Carcinoma.Nutrients · 2026Article
- Timing matters: gastrostomy placement and outcomes in patients with head and neck cancer undergoing chemoradiotherapy.Frontiers in nutrition · 2026Article
- Survival and Prognostic Factors in Unresectable Head and Neck Cancer Patients.Journal of clinical medicine · 2025Article
- Prognostic Effect of Patterns of Local Extension and Satellitosis in cT3 Squamous Cell Carcinoma of the Oral Tongue: A Prospective Observational Study.Head & neck · 2025Observational
- Prospective Cohort Study Identifies Medical Predictors of Treatment-Related Oral Toxicities in Oral and Oropharyngeal Cancer Patients.Dentistry journal · 2024Article
- Predictive value of the Adult Comorbidity Evaluation 27 on adverse surgical outcomes and survival in elderly with advanced epithelial ovarian cancer undergoing cytoreductive surgery.European journal of medical research · 2024Article
- The total amount of fluid administered is associated with postoperative complications in head and neck cancer surgery.World journal of otorhinolaryngology - head and neck surgery · 2023Article
- Management of Older Patients with Head and Neck Cancer: A Comprehensive Review.Advances in therapy · 2023Review
- Treatment Considerations for Patients with Locoregionally Advanced Head and Neck Cancer with a Contraindication to Cisplatin.Current treatment options in oncology · 2023Review
- Review
- Epigenetic biomarkers of ageing are predictive of mortality risk in a longitudinal clinical cohort of individuals diagnosed with oropharyngeal cancer.Clinical epigenetics · 2022Article
- Postoperative Complications of Free Flap Reconstruction in Moderate-Advanced Head and Neck Squamous Cell Carcinoma: A Prospective Cohort Study Based on Real-World Data.Frontiers in oncology · 2022Article
- The Impact of the COVID-19 Pandemic on Head and Neck Cancer Diagnosis in the Piedmont Region, Italy: Interrupted Time-Series Analysis.Frontiers in public health · 2022Article
- ACE-27 as a prognostic tool of severe acute toxicities in patients with head and neck cancer treated with chemoradiotherapy: a real-world, prospective, observational study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Observational
- Article
- Incidence and Survival for Head and Neck Cancers in Estonia, 1996-2016: A Population-Based Study.Clinical epidemiology · 2021Article
- Four Lessons Learned from Complications in Head and Neck Microvascular Reconstructions and Prevention Strategies.Plastic and reconstructive surgery. Global open · 2021Article
- Cancer epidemiology literature from India: Does it reflect the reality?Journal of public health (Oxford, England) · 2020Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundPeople with head and neck cancer have higher comorbidity levels but it remains unclear if pretreatment comorbidity is an independent prognosticator in head and neck cancer.
methodsSurvival analyses were performed using data from participants in a UK multicentre cohort study with cancers of the oral cavity (n = 668), oropharynx (n = 1074), and larynx (n = 530). Survival analyses were incrementally adjusted for age, sex, marital status, income, education, stage, alcohol, and smoking.
resultsAfter adjusting for demographic, clinical, and behavioral confounders, higher baseline comorbidity was associated with reduced overall survival (mild comorbidity HR = 1.4, 95% CI = 1.1, 1.7; moderate comorbidity HR = 1.7, 95% CI = 1.3, 2.2; severe comorbidity HR = 2.8, 95% CI = 1.9, 4.; P-trend<.001).
conclusionsOur findings suggest that comorbidity is an independent prognosticator for overall survival in head and neck cancer. Comorbid illnesses should be considered in the assessment and treatment planning of people with head and neck cancer.
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