Evidence map›Paper›PMID 30549020›Full record

ReviewComprehensive Physiology2018

Lymphatic Vessel Network Structure and Physiology.

Jerome W Breslin, Ying Yang, Joshua P Scallan, Richard S Sweat, Shaquria P Adderley, Walter L Murfee

Open access · greenAbstract readReview
In one paragraph

Review in Comprehensive Physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 212 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
212citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

212 citing papers in PubMed, 1 synthesis or guideline pooled it, 340 citations in OpenAlex.

  1. Mucosal immune response in biology, disease prevention and treatment.Signal transduction and targeted therapy · 2025
    Pooled it
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  17. From blood vessels to lymphatics and back again.Function (Oxford, England) · 2026
    Article
  18. Review
  19. Review
  20. Article

152 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jerome W BreslinDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Ying YangDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Joshua P ScallanDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Richard S SweatDepartment of Biomedical Engineering, Tulane University, New Orleans, Tampa, Louisiana, USA.
Shaquria P AdderleyDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Walter L MurfeeDepartment of Biomedical Engineering, University of Florida, Gainesville, Florida, USA.
University of South Florida · USTulane University · USUniversity of Florida · US

Funding

Regulatory Mechanisms for Resolution of Inflammatory Microvascular LeakageR01HL098215 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI BRESLIN, JEROME W · 2011 to 2015
$1.8M
S1P-fluid therapy to reduce hemorrhagic shock & intoxication-induced injuryR01GM120774 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI BRESLIN, JEROME W · 2016 to 2019
$1.2M
Angiogenesis Model for Aging ResearchR01AG049821 · NIA · UNIVERSITY OF FLORIDA · PI MURFEE, WALTER L · 2016 to 2019
$1.0M
Lymphatic Endothelial Permeability as a Regulator of Mesenteric Adipose DepositioR00HL124142 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI SCALLAN, JOSHUA PAUL · 2016 to 2018
$717k
NHLBI NIH HHS L40 HL097863NHLBI NIH HHS R00 HL124142NHLBI NIH HHS R01 HL098215NIA NIH HHS R01 AG049821NIGMS NIH HHS R01 GM120774
6 · The paper itself

Abstract

The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue, which has the holistic function to maintain the local physiologic environment for every cell in all tissues of the body. The lymphatic system maintains extracellular fluid homeostasis favorable for optimal tissue function, removing substances that arise due to metabolism or cell death, and optimizing immunity against bacteria, viruses, parasites, and other antigens. This article provides a comprehensive review of important findings over the past century along with recent advances in the understanding of the anatomy and physiology of lymphatic vessels, including tissue/organ specificity, development, mechanisms of lymph formation and transport, lymphangiogenesis, and the roles of lymphatics in disease. © 2019 American Physiological Society. Compr Physiol 9:207-299, 2019.

Indexed as

AnimalsHomeostasisHumansLymphatic System

Identifiers

PMID30549020
PMCPMC6459625
OpenAlexW2904736348

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.