ReviewComprehensive Physiology2018
Contribution of Adipose Tissue Inflammation to the Development of Type 2 Diabetes Mellitus.
Review in Comprehensive Physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 244 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
244 citing papers in PubMed, 3 syntheses or guidelines pooled it, 375 citations in OpenAlex.
- Unraveling the rationale and conducting a comprehensive assessment of KD025 (Belumosudil) as a candidate drug for inhibiting adipogenic differentiation-a systematic review.Naunyn-Schmiedeberg's archives of pharmacology · 2024Pooled it
- Probiotics' effect on visceral and subcutaneous adipose tissue: a systematic review of randomized controlled trials.European journal of clinical nutrition · 2022Pooled it
- Association of rs2910164 in miR-146a with type 2 diabetes mellitus: A case-control and meta-analysis study.Frontiers in endocrinology · 2022Pooled it
- Stage-specific elevation of MPO and NE mRNA expression in diabetic kidney disease and their independent associations with albuminuria.Molecular biology reports · 2026Article
- A distinct form of fat fibrosis is linked to insulin resistance in people with HIV.JCI insight · 2026Observational
- The Influence of Genetic Background and Housing Conditions on Spontaneous Obesity in Captive-Bred Rhesus Monkeys (Macaca mulatta).Journal of medical primatology · 2026Article
- A Review of Semi-Mechanistic HbA1c Models in People with Type 2 Diabetes: Strengths, Limitations, and Applications.Journal of clinical pharmacology · 2026Review
- Genetic Correlation and Causal Inference Between Female Fat Distribution and Preeclampsia: An Integrative Genomic Study.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Dietary intake, fatty acid in adipose tissue and cardio-metabolic health: cross-sectional study from the TwinsUK cohort.Nutrition & diabetes · 2026Article
- Animal models in molecular biology research: Challenges, ethical imperatives, and the path to human-relevant translation.Animal models and experimental medicine · 2026Review
- Article
- Adipose cellularity and long-term development of impaired glucose metabolism: Swedish cohort study from 1988 through 2016.EBioMedicine · 2026Article
- mInternational journal of molecular medicine · 2026Review
- Article
- Article
- The Natural History of Prediabetes and Cardiovascular Disease in the Pediatric Population.Biomedicines · 2026Review
- Beyond BMI: Ultrasound-Detected Visceral Adiposity as a Predictor of Early Cardiometabolic Dysfunction in Youth with Type 1 Diabetes.Children (Basel, Switzerland) · 2026Article
- Acute Effects of Exercise on Metabolic, Inflammatory, and Immune Markers in Adolescent Girls with Normal Weight or Overweight/Obesity.Sports (Basel, Switzerland) · 2026Article
- Adipokine patterns in type 1 and type 2 diabetes mellitus: comparative analysis of adiponectin-leptin ratio, visfatin, and TNF-α.Frontiers in endocrinology · 2026Article
- Machine learning algorithms for predicting glycemic control and weight loss outcomes in GLP-1 receptor agonist users.Frontiers in artificial intelligence · 2026Article
184 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The objective of this comprehensive review is to summarize and discuss the available evidence of how adipose tissue inflammation affects insulin sensitivity and glucose tolerance. Low-grade, chronic adipose tissue inflammation is characterized by infiltration of macrophages and other immune cell populations into adipose tissue, and a shift toward more proinflammatory subtypes of leukocytes. The infiltration of proinflammatory cells in adipose tissue is associated with an increased production of key chemokines such as C-C motif chemokine ligand 2, proinflammatory cytokines including tumor necrosis factor α and interleukins 1β and 6 as well as reduced expression of the key insulin-sensitizing adipokine, adiponectin. In both rodent models and humans, adipose tissue inflammation is consistently associated with excess fat mass and insulin resistance. In humans, associations with insulin resistance are stronger and more consistent for inflammation in visceral as opposed to subcutaneous fat. Further, genetic alterations in mouse models of obesity that reduce adipose tissue inflammation are-almost without exception-associated with improved insulin sensitivity. However, a dissociation between adipose tissue inflammation and insulin resistance can be observed in very few rodent models of obesity as well as in humans following bariatric surgery- or low-calorie-diet-induced weight loss, illustrating that the etiology of insulin resistance is multifactorial. Taken together, adipose tissue inflammation is a key factor in the development of insulin resistance and type 2 diabetes in obesity, along with other factors that likely include inflammation and fat accumulation in other metabolically active tissues. © 2019 American Physiological Society. Compr Physiol 9:1-58, 2019.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.