Evidence map›Paper›PMID 30548798›Full record

ArticleMicrobial biotechnology2019

Meta synthetic biology: controlling the evolution of engineered living systems.

Morten H H Nørholm

Abstract read
In one paragraph

Article in Microbial biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Engineering a Novel Probiotic Toolkit inACS synthetic biology · 2024
    Article
  3. Synthetic biology beyond borders.Microbial biotechnology · 2021
    Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Morten H H NørholmMicrobial Evolution and Synthetic Biology Group, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800 , Kgs. Lyngby, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A major aim of synthetic biology is the design of robust living systems for real-world applications. In seemingly contrast, evolution changes the living, exploring new survival strategies in response to environmental challenges. How do we cope with this paradox? Can we control or even exploit the molecular mechanisms of evolution for biotechnological and biosustainable innovation and will the principles of engineering lead to fundamental insights in evolutionary biology? A merger of synthetic biology with experimental evolution is occurring and it will radically accelerate the development of these scientific disciplines.

Indexed as

Adaptation, BiologicalBiological EvolutionMetabolic EngineeringMutationSelection, GeneticSynthetic Biology

Identifiers

PMID30548798
PMCPMC6302734

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.