ArticlePest management science2019
Pyrethroid neurotoxicity studies with bifenthrin indicate a mixed Type I/II mode of action.
Article in Pest management science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Recent Advanced Technologies for the Characterization of Xenobiotic-Degrading Microorganisms and Microbial Communities.Frontiers in bioengineering and biotechnology · 2021Pooled it
- Bifenthrin Under Scrutiny: Revisiting Toxicological Evidence Amid Regulatory Gaps.Journal of applied toxicology : JAT · 2026Review
- Bifenthrin Residues in Table Grapevine: Method Optimization, Dissipation and Removal of Residues in Grapes and Grape Leaves.Plants (Basel, Switzerland) · 2024Article
- Review
- Risk assessment of pesticide residues ingestion in food offered by institutional restaurant menus.PloS one · 2024Article
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- Biodegradation of the Pesticides Bifenthrin and Fipronil by Bacillus Isolated from Orange Leaves.Applied biochemistry and biotechnology · 2023Article
- LC-MS/MS Method Minimizing Matrix Effect for the Analysis of Bifenthrin and Butachlor in Chinese Chives and Its Application for Residual Study.Foods (Basel, Switzerland) · 2023Article
- Highly efficient degradation of cypermethrin by a co-culture ofFrontiers in microbiology · 2022Article
- Article
- Article
- Exposure to permethrin or chlorpyrifos causes differential dose- and time-dependent behavioral effects at early larval stages of an endangered teleost species.Endangered species research · 2021Article
- Effect of Lambdacyhalothrin on Locomotor Activity, Memory, Selected Biochemical Parameters, Tumor Necrosis Factor α, and Interleukin 1ß in a Mouse Model.International journal of environmental research and public health · 2020Article
- Bifenthrin exposure causes hyperactivity in early larval stages of an endangered fish species at concentrations that occur during their hatching season.Aquatic toxicology (Amsterdam, Netherlands) · 2020Article
- The history of extensive structural modifications of pyrethroids.Journal of pesticide science · 2019Article
- Insight Into Microbial Applications for the Biodegradation of Pyrethroid Insecticides.Frontiers in microbiology · 2019Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBifenthrin is usually considered a Type I pyrethroid, because it lacks an α-CN group present in Type II pyrethroids, but some previous studies suggest a mixed Type I/II mode-of-action. Results are presented for bifenthrin in a rat developmental neurotoxicity (DNT) study along with effects on Na currents in human VGSC subtypes. Molecular modeling comparisons were also made for bifenthrin and other pyrethroids.
resultsIn a rat DNT study, bifenthrin produced tremors and clonic convulsions in dams and pups and slightly reduced acoustic startle response amplitude, and increased Tmax, at PND20 in females. Similar blood levels of bifenthrin were measured in dams and pups at each dose level i.e. no concentration in pups. In human VGSC experiments, using the Nav1.8 subtype, bifenthrin's effects on inactivation were slight, as for Type II pyrethroids, but without large prolongation of the tail current (deactivation) seen with Type II. Molecular modeling of bifenthrin indicates that the o-Me group may occupy a similar space to the α-CN group of cypermethrin and fenpropathrin.
conclusionIn a DNT study and on human Nav1.8 tail currents bifenthrin showed Type I and II effects, similar to some published studies. Overall, bifenthrin acts as a mixed Type I/II pyrethroid. © 2018 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
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