ArticleHuman brain mapping2019
Impact of sex and reproductive status on memory circuitry structure and function in early midlife using structural covariance analysis.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Distinct intrinsic neural connectivity of an emotion regulation network across the menopausal transition.Comprehensive psychoneuroendocrinology · 2026Article
- Estradiol modulated brain connectivity in females during midlife performing an episodic memory task.Brain imaging and behavior · 2026Article
- Sex-dependent grey matter atrophy in Alzheimer's disease progression.Brain communications · 2026Article
- Sex differences in the impact of genetic and clinical risk factors for Alzheimer's disease in midlife.Journal of Alzheimer's disease : JAD · 2025Article
- A cross-species analysis of neuroanatomical covariance sex differences in humans and mice.Biology of sex differences · 2025Article
- Cognitive Function in Peri- and Postmenopausal Women: Implications for Considering Iron Supplementation.Nutrients · 2025Review
- Leukocyte telomere length and memory circuitry and cognition in early aging: Impact of sex and menopausal status.Hormones and behavior · 2024Article
- Changes in Structural Covariance among Olfactory-related Brain Regions in Anosmia Patients.Experimental neurobiology · 2024Article
- Cognitive Problems in Perimenopause: A Review of Recent Evidence.Current psychiatry reports · 2023Review
- A review of multi-modal magnetic resonance imaging studies on perimenopausal brain: a hint towards neural heterogeneity.European radiology · 2023Review
- Brain volumetric changes in menopausal women and its association with cognitive function: a structured review.Frontiers in aging neuroscience · 2023Review
- Infections During Pregnancy and Risks for Adult Psychosis: Findings from the New England Family Study.Current topics in behavioral neurosciences · 2023Article
- Cognitive deficits, clinical variables, and white matter microstructure in schizophrenia: a multisite harmonization study.Molecular psychiatry · 2022Article
- Multimodal MRI examination of structural and functional brain changes in older women with breast cancer in the first year of antiestrogen hormonal therapy.Breast cancer research and treatment · 2022Observational
- The selective contributions of right cerebellar lobules to reading.Brain structure & function · 2022Article
- Ovarian steroid hormones: A long overlooked but critical contributor to brain aging and Alzheimer's disease.Frontiers in aging neuroscience · 2022Review
- The development of structural covariance networks during the transition from childhood to adolescence.Scientific reports · 2021Article
- Impact of sex and reproductive status on memory circuitry structure and function in early midlife using structural covariance analysis.Human brain mapping · 2019Article
- The Middle-Aged Brain: Biological sex and sex hormones shape memory circuitry.Current opinion in behavioral sciences · 2018Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Research on age-related memory alterations traditionally targets individuals aged ≥65 years. However, recent studies emphasize the importance of early aging processes. We therefore aimed to characterize variation in brain gray matter structure in early midlife as a function of sex and menopausal status. Subjects included 94 women (33 premenopausal, 29 perimenopausal, and 32 postmenopausal) and 99 demographically comparable men from the New England Family Study. Subjects were scanned with a high-resolution T1 sequence on a 3 T whole body scanner. Sex and reproductive-dependent structural differences were evaluated using Box's M test and analysis of covariances (ANCOVAs) for gray matter volumes. Brain regions of interest included dorsolateral prefrontal cortex (DLPFC), inferior parietal lobule (iPAR), anterior cingulate cortex (ACC), hippocampus (HIPP), and parahippocampus. While we observed expected significant sex differences in volume of hippocampus with women of all groups having higher volumes than men relative to cerebrum size, we also found significant differences in the covariance matrices of perimenopausal women compared with postmenopausal women. Associations between ACC and HIPP/iPAR/DLPFC were higher in postmenopausal women and correlated with better memory performance. Findings in this study underscore the importance of sex and reproductive status in early midlife for understanding memory function with aging.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.