Evidence map›Paper›PMID 30548581›Full record

ArticleJournal of the American Geriatrics Society2019

Geriatric Assessment in Older Adults with Multiple Myeloma.

Tanya M Wildes, Sascha A Tuchman, Heidi D Klepin, Joseph Mikhael, Kathryn Trinkaus, Keith Stockerl-Goldstein, Ravi Vij, Graham Colditz

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Geriatrics Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

  1. Pooled it
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  15. Article
  16. Health-related quality of life and use of medication with anticholinergic activity in patients with multiple myeloma.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Article
  17. Partnering With All Patients: Ensuring Shared Decision Making and Evidence-Based Management for Underrepresented Groups With Multiple Myeloma.American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting · 2023
    Article
  18. Fitness and frailty in myeloma.Hematology. American Society of Hematology. Education Program · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Tanya M WildesDivision of Oncology, Washington University School of Medicine, St Louis, Missouri.ORCID 0000-0002-1479-7626
Sascha A TuchmanDivision of Hematological Malignancies, Duke Cancer Institute, Durham, North Carolina.
Heidi D KlepinSection on Hematology and Oncology, Wake Forest School of Medicine, Winston Salem, North Carolina.
Joseph MikhaelDepartment of Medicine, Mayo Clinic, Phoenix, Arizona.
Kathryn TrinkausDivision of Biostatistics, Washington University School of Medicine, St Louis, Missouri.
Keith Stockerl-GoldsteinDivision of Oncology, Washington University School of Medicine, St Louis, Missouri.
Ravi VijDivision of Oncology, Washington University School of Medicine, St Louis, Missouri.
Graham ColditzDivision of Public Health Sciences, Washington University School of Medicine, St Louis, Missouri.
Washington University in St. Louis · USUniversity of North Carolina at Chapel Hill · USWake Forest University · USWinnMed · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Washington University Paul Calabresi K12 Career Development Award for Clinical OncologyK12CA167540 · NCI · WASHINGTON UNIVERSITY · PI John F. Dipersio, Ramaswamy Govindan · 2012 to 2026
$11.7M
PILOT STUDY OF GERIATRIC ASSESSMENTS IN SENIOR ADULTS WITH MULTIPLE MYELOMAR03AG042374 · NIA · WASHINGTON UNIVERSITY · PI WILDES, TANYA M · 2012 to 2013
$148k
NCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NCI NIH HHS K12 CA167540NCI NIH HHS K12CA167540NIA NIH HHS R03 AG042374NIH
6 · The paper itself

Abstract

BACKGROUND/

objectivesThe incidence of myeloma in older adults is increasing, yet little is known about geriatric impairments in these patients. We aimed to examine the prevalence of geriatric impairments in older adults with myeloma and the association between geriatric assessment and autologous stem cell transplant eligibility.

designProspective cohort study.

settingTwo academic medical centers.

participantsA total of 40 adults 65 years and older with newly diagnosed myeloma were enrolled. MEASUREMENT: Participants completed a primarily self-administered geriatric assessment, including measures of functional status, comorbidities, polypharmacy, psychosocial status, social support, quality of life, cognition, and physical performance. Outcomes were autologous stem cell transplant eligibility and receipt.

resultsForty patients enrolled; their mean age was 71 years. Geriatric impairments were common: 62% reported dependence in one or more instrumental activities of daily living (IADL), 76.9% had polypharmacy (four or more medications), and 47.5% had one or more comorbidities. Median time on the Timed Up and Go was 13.3 ± 4.9 seconds. Those considered candidates for autologous stem cell transplant (N = 26) were younger, with fewer comorbidities, better performance status, and faster performance on the Timed Up and Go test. Factors independently associated with receiving autologous stem cell transplant (N = 21) included age and IADL dependence.

conclusionImpairments in geriatric domains are common in this population, even among those considered to have a good performance status. Geriatric assessment domains are associated with both transplant eligibility and receipt. J Am Geriatr Soc 67:987-991, 2019.

Indexed as

Activities of Daily LivingComorbidityGeriatric AssessmentPolypharmacyAgedCognitionFemaleHematopoietic Stem Cell TransplantationHumansMaleMultiple MyelomaProspective StudiesQuality of LifeSelf ReportSurveys and Questionnairesagedelderly personsgeriatric assessmenthematopoietic stem cell transplantationmultiple myeloma

Identifiers

PMID30548581
PMCPMC7006442
OpenAlexW2905042952

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.