Evidence map›Paper›PMID 30548427›Full record

ArticlePhysiological reports2018

Impaired Kv7 channel function in cerebral arteries of a tauopathy mouse model (rTg4510).

Inge E M de Jong, Thomas A Jepps

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Amyloid β alters vascular CaThe Journal of physiology · 2025
    Article
  4. Vascular Function and Ion Channels in Alzheimer's Disease.Microcirculation (New York, N.Y. : 1994) · 2024
    Review
  5. Article
  6. Review
  7. Heterozygous Deletion of Epilepsy GeneFrontiers in behavioral neuroscience · 2022
    Article
  8. mTOR Attenuation with Rapamycin Reverses Neurovascular Uncoupling and Memory Deficits in Mice Modeling Alzheimer's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  9. Review
  10. Kv7 Channels in Lung Diseases.Frontiers in physiology · 2020
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Inge E M de JongDepartment of Neurodegeneration, Lundbeck A/S, Valby, Denmark.
Thomas A JeppsDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-9903-714X
Lundbeck (Denmark) · DKUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In tauopathies, such as Alzheimer's disease with or without concomitant amyloid β plaques, cerebral arteries display pathological remodeling, leading to reduced brain tissue oxygenation and cognitive impairment. The precise mechanisms that underlie this vascular dysfunction remain unclear. Kv7 voltage-dependent K

Indexed as

Action PotentialsAnimalsCerebral ArteriesHEK293 CellsHumansKCNQ Potassium ChannelsMaleMicePotassium Channels, Voltage-GatedTauopathiesKCNE5 protein, humanKCNQ Potassium ChannelsPotassium Channels, Voltage-Gatedcerebral arteryKCNEKCNQKv7 ChannelsrTg4510tauopathies

Identifiers

PMID30548427
PMCPMC6289909
OpenAlexW2904969689

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.