Evidence map›Paper›PMID 30548403›Full record

ArticleJournal of diabetes investigation2019

Genetic variants in DNMT1 and the risk of cardiac autonomic neuropathy in women with type 1 diabetes.

Daniele Pereira Santos-Bezerra, Sharon Nina Admoni, Rosana Cristina Mori, Tatiana Souza Pelaes, Ricardo Vesoni Perez, Cleide Guimarães Machado, Maria Beatriz Monteiro, Maria Candida Parisi, Elizabeth Joao Pavin, Marcia Silva Queiroz and 3 more

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In one paragraph

Article in Journal of diabetes investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Daniele Pereira Santos-BezerraLaboratory of Carbohydrates and Radioimuneassays (LIM-18), Clinical Hospital, Medical School, University of Sao Paulo, Universidade de Sao Paulo, Sao Paulo, Brazil.
Sharon Nina AdmoniLaboratory of Carbohydrates and Radioimuneassays (LIM-18), Clinical Hospital, Medical School, University of Sao Paulo, Universidade de Sao Paulo, Sao Paulo, Brazil.
Rosana Cristina MoriDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, University of São Paulo, São Paulo, Brazil.
Tatiana Souza PelaesLaboratory of Carbohydrates and Radioimuneassays (LIM-18), Clinical Hospital, Medical School, University of Sao Paulo, Universidade de Sao Paulo, Sao Paulo, Brazil.
Ricardo Vesoni PerezLaboratory of Carbohydrates and Radioimuneassays (LIM-18), Clinical Hospital, Medical School, University of Sao Paulo, Universidade de Sao Paulo, Sao Paulo, Brazil.
Cleide Guimarães MachadoDivision of Oftalmology, Clinical Hospital, Medical School, University of Sao Paulo, Sao Paulo, Brazil.
Maria Beatriz MonteiroLaboratory of Carbohydrates and Radioimuneassays (LIM-18), Clinical Hospital, Medical School, University of Sao Paulo, Universidade de Sao Paulo, Sao Paulo, Brazil.
Maria Candida ParisiDepartment of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Sao Paulo, Brazil.
Elizabeth Joao PavinDepartment of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Sao Paulo, Brazil.
Marcia Silva QueirozDivision of Endocrinology, Clinical Hospital, Medical School, University of Sao Paulo, Universidade de Sao Paulo, Sao Paulo, Brazil.
Marisa PassarelliLaboratory of Carbohydrates and Radioimuneassays (LIM-18), Clinical Hospital, Medical School, University of Sao Paulo, Sao Paulo, Brazil.
Ubiratan Fabres MachadoDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, University of São Paulo, São Paulo, Brazil.
Maria Lucia Correa-GiannellaLaboratory of Carbohydrates and Radioimuneassays (LIM-18), Clinical Hospital, Medical School, University of Sao Paulo, Universidade de Sao Paulo, Sao Paulo, Brazil.ORCID http://orcid.org/0000-0003-3655-4446
Universidade de São Paulo · BRUniversidade Estadual de Campinas (UNICAMP) · BR

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2012/04831-1
6 · The paper itself

Abstract

AIMS/

introductionEpigenetics participate in the pathogenesis of metabolic memory, a situation in which hyperglycemia exerts prolonged deleterious effects even after its normalization. We tested the hypothesis that genetic variants in an epigenetic gene could predispose to diabetes complications. MATERIAL AND

methodsWe assessed the frequency of five single-nucleotide polymorphisms in the gene encoding deoxyribonucleic acid methytransferase 1 (DNMT1; rs8112895, rs7254567, rs11085721, rs17291414 and rs10854076), and their associations with diabetic kidney disease, retinopathy, distal polyneuropathy and autonomic cardiovascular neuropathy in 359 individuals with long-term type 1 diabetes.

resultsNone of the single-nucleotide polymorphisms studied was significantly associated with the presence of chronic complications in the overall population. However, after sex stratification, the minor allele C of rs11085721 conferred risk for cardiovascular neuropathy in women after adjustment for confounding variables (odds ratio 2.32; 95% confidence interval 1.26-4.33; P = 0.006).

conclusionsThe fact that heterozygous mutations in DNMT1 are associated with hereditary sensory autonomic neuropathy provides plausibility to the present finding. If confirmed in independent samples, it suggests that genetic variants in epigenetic genes might predispose to more or fewer epigenetic changes in the face of similar metabolic derangements triggered by hyperglycemia, constituting the "genetics of epigenetics" for microvascular diabetes complications.

Indexed as

Polymorphism, Single NucleotideAdultAutonomic Nervous SystemBiomarkersDiabetes Mellitus, Type 1Diabetic CardiomyopathiesDiabetic NeuropathiesDNA (Cytosine-5-)-Methyltransferase 1FemaleFollow-Up StudiesHumansMiddle AgedPrognosisBiomarkersDNA (Cytosine-5-)-Methyltransferase 1DNMT1 protein, humanChronic complicationsEpigeneticsMetabolic memory

Identifiers

PMID30548403
PMCPMC6626951
OpenAlexW2903807646

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.