ArticleAngewandte Chemie (International ed. in English)2019
Telescoped, Divergent, Chemoselective C1 and C1-C1 Homologation of Imine Surrogates: Access to Quaternary Chloro- and Halomethyl-Trifluoromethyl Aziridines.
Article in Angewandte Chemie (International ed. in English), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Article
- Synthesis and Application of Bioactive N-Functionalized Aziridines.Angewandte Chemie (International ed. in English) · 2025Review
- Monofluoromethylation ofInternational journal of molecular sciences · 2023Review
- Base-mediated homologative rearrangement of nitrogen-oxygen bonds ofChemical science · 2023Article
- Article
- Novel Class of Proteasome Inhibitors: In Silico and In Vitro Evaluation of Diverse Chloro(trifluoromethyl)aziridines.International journal of molecular sciences · 2022Article
- 29th Annual GP2A Medicinal Chemistry Conference.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Consecutive and Selective Double Methylene Insertion of Lithium Carbenoids to Isothiocyanates: A Direct Assembly of Four-Membered Sulfur-Containing Cycles.Angewandte Chemie (International ed. in English) · 2021Article
- Pseudo-Dipeptide Bearing α,α-Difluoromethyl Ketone Moiety as Electrophilic Warhead with Activity against Coronaviruses.International journal of molecular sciences · 2021Article
- Solvation Effects on the Structure and Stability of Alkali Metal Carbenoids.Angewandte Chemie (International ed. in English) · 2021Article
- A sustainable strategy for the straightforward preparation of 2Beilstein journal of organic chemistry · 2021Article
- Chemoselective Homologation-Deoxygenation Strategy Enabling the Direct Conversion of Carbonyls into (Organic letters · 2020Article
- Direct and Chemoselective Electrophilic Monofluoromethylation of Heteroatoms (Organic letters · 2020Article
- Sustainable Asymmetric Organolithium Chemistry: Enantio- and Chemoselective Acylations through Recycling of Solvent, Sparteine, and Weinreb "Amine".ChemSusChem · 2019Article
- Telescoped, Divergent, Chemoselective C1 and C1-C1 Homologation of Imine Surrogates: Access to Quaternary Chloro- and Halomethyl-Trifluoromethyl Aziridines.Angewandte Chemie (International ed. in English) · 2019Article
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6 authors.
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Abstract
A conceptually novel, high-yielding, mono- or bis-homologation was realized with lithium halocarbenoids and enables the one-step, fully chemocontrolled assembly of a new class of quaternary trifluoromethyl aziridines. Trifluoroacetimidoyl chlorides (TFAICs) act as convenient electrophilic platforms, enabling the addition of either one or two homologating elements by simply controlling the stoichiometry of the process. Mechanistic studies highlighted that the homologation event, carried out with two different carbenoids (LiCH
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