ArticleHuman brain mapping2019
Multidelay multiparametric arterial spin labeling perfusion MRI and mild cognitive impairment in early stage Parkinson's disease.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Global Alterations of Whole Brain Structural Connectome in Parkinson's Disease: A Meta-analysis.Neuropsychology review · 2023Pooled it
- Abnormalities of cerebral blood flow and the regional brain function in Parkinson's disease: a systematic review and multimodal neuroimaging meta-analysis.Frontiers in neurology · 2023Pooled it
- Meta-Analysis of Cognition in Parkinson's Disease Mild Cognitive Impairment and Dementia Progression.Neuropsychology review · 2022Pooled it
- Neurovascular coupling dysfunction of the frontal‒thalamic circuit in postconcussion syndrome.Brain imaging and behavior · 2026Article
- Precision of automatically generated generic regions of interest for direct assessment of perfusion-MRI.Frontiers in physiology · 2026Article
- The differential relationship between white matter cerebrovascular perfusion and microstructure between normal cognition and mild cognitive impairment.Journal of Alzheimer's disease : JAD · 2025Article
- Abnormal Cerebrovascular Activity, Perfusion, and Glymphatic Clearance in Lewy Body Diseases.Movement disorders : official journal of the Movement Disorder Society · 2024Review
- Reduced and Delayed Cerebrovascular Reactivity in Patients with Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2023Article
- Brain functional network abnormalities in parkinson's disease with mild cognitive impairment.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Application of 3D-ASL in hemodynamic analysis and prognosis evaluation of vascular cognitive impairment.American journal of translational research · 2022Article
- Altered Prefrontal Blood Flow Related With Mild Cognitive Impairment in Parkinson's Disease: A Longitudinal Study.Frontiers in aging neuroscience · 2022Article
- Topologically convergent and divergent morphological gray matter networks in early-stage Parkinson's disease with and without mild cognitive impairment.Human brain mapping · 2021Article
- Mild cognitive impairment with Lewy bodies: blood perfusion with arterial spin labelling.Journal of neurology · 2021Article
- Reliability and Reproducibility of Hadamard Encoded Pseudo-Continuous Arterial Spin Labeling in Healthy Elderly.Frontiers in neuroscience · 2021Article
- Cortical hypoperfusion in patients with idiopathic rapid eye movement sleep behavior disorder detected with arterial spin-labeled perfusion MRI.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- Multidelay multiparametric arterial spin labeling perfusion MRI and mild cognitive impairment in early stage Parkinson's disease.Human brain mapping · 2019Article
- Parkinson's Disease-Mild Cognitive Impairment (PD-MCI): A Useful Summary of Update Knowledge.Frontiers in aging neuroscience · 2019Article
- Neuroanatomical and functional substrates of the hypomanic personality trait and its prediction on aggression.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
Mild cognitive impairment (MCI), a well-defined nonmotor manifestation of Parkinson's disease (PD), greatly impairs functioning and quality of life. However, the contribution of cerebral perfusion, quantified by arterial spin labeling (ASL), to MCI in PD remains poorly understood. The selection of an optimal delay time is difficult for single-delay ASL, a problem which is avoided by multidelay ASL. This study uses a multidelay multiparametric ASL to investigate cerebral perfusion including cerebral blood flow (CBF) and arterial transit time (ATT) in early stage PD patients exhibiting MCI using a voxel-based brain analysis. Magnetic resonance imaging data were acquired on a 3.0 T system at rest in 39 early stage PD patients either with MCI (PD-MCI, N = 22) or with normal cognition (PD-N, N = 17), and 36 age- and gender-matched healthy controls (HCs). CBF and ATT were compared among the three groups with SPM using analysis of variance followed by post hoc analyses to define regional differences and examine their relationship to clinical data. PD-MCI showed prolonged ATT in right thalamus compared to both PD-N and HC, and in right supramarginal gyrus compared to HC. PD-N showed shorter ATT in left superior frontal cortex compared to HC. Prolonged ATT in right thalamus was negatively correlated with the category fluency test (p = .027, r = -0.495) in the PD-MCI group. This study shows that ATT may be a more sensitive marker than CBF for the MCI, and highlights the potential role of thalamus and inferior parietal region for MCI in early stage PD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.