Evidence map›Paper›PMID 30547882›Full record

ArticleeLife2018

Genetic analysis reveals functions of atypical polyubiquitin chains.

Fernando Meza Gutierrez, Deniz Simsek, Arda Mizrak, Adam Deutschbauer, Hannes Braberg, Jeffrey Johnson, Jiewei Xu, Michael Shales, Michelle Nguyen, Raquel Tamse-Kuehn and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Emerging Roles of Non-proteolytic Ubiquitination in Tumorigenesis.Frontiers in cell and developmental biology · 2022
    Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Fernando Meza Gutierrez *Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States.ORCID http://orcid.org/0000-0002-5601-7202
Deniz Simsek *Amgen Research, San Francisco, United States.
Arda MizrakDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States.
Adam DeutschbauerLawrence Berkeley National Laboratory, Berkeley, United States.
Hannes BrabergDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States.
Jeffrey JohnsonDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States.
Jiewei XuDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States.
Michael ShalesDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States.
Michelle NguyenStanford Genome Technology Center, Stanford University, Stanford, United States.
Raquel Tamse-KuehnStanford Genome Technology Center, Stanford University, Stanford, United States.
Curt PalmStanford Genome Technology Center, Stanford University, Stanford, United States.
Lars M SteinmetzStanford Genome Technology Center, Stanford University, Stanford, United States.
Nevan J KroganDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States.
David P ToczyskiDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States.ORCID http://orcid.org/0000-0001-5924-0365
University of California, San Francisco · USStanford University · USAmgen (United States) · USLawrence Berkeley National Laboratory · US

Funding

Regulation by post-translation modifications in response to stressR35GM118104 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TOCZYSKI, DAVID PAUL · 2016 to 2025
$7.2M
NIGMS NIH HHS R35 GM118104NIH HHS R35 GM118104
6 · The paper itself

Abstract

Although polyubiquitin chains linked through all lysines of ubiquitin exist, specific functions are well-established only for lysine-48 and lysine-63 linkages in

Indexed as

Gene Expression Regulation, FungalAmino Acid SubstitutionAnaphase-Promoting Complex-CyclosomeArginineBiological TransportCell CycleGenetic EngineeringLysineMicroarray AnalysisPolyubiquitinProtein BindingSaccharomyces cerevisiaeThreonineUbiquitinUbiquitinationAnaphase-Promoting Complex-CyclosomeArginineLysinePolyubiquitinThreonineUbiquitinAPCbiochemistrychemical biologygeneticsgenomicsK11S. cerevisiaeubiquitin

Identifiers

PMID30547882
PMCPMC6305200
OpenAlexW2905365267

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.