ArticleBMC genomics2018
Daphnia galeata responds to the exposure to an ichthyosporean gut parasite by down-regulation of immunity and lipid metabolism.
Article in BMC genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Transcriptomic Landscape Reveals Immunity Related Trade-Offs in an Invertebrate-Fungal Host-Parasite System.Molecular ecology · 2026Article
- Counterproductive: coinfection of a water flea by a fungus and a microsporidium reduces the reproductive outputs of all parties.Scientific reports · 2026Article
- Heavy-metal Pollution Affects Daphnia Fitness by Altering Diversity of the Gut Microbiota.Microbial ecology · 2025Article
- Differential gene expression analysis pipelines and bioinformatic tools for the identification of specific biomarkers: A review.Computational and structural biotechnology journal · 2024Review
- Differences in alternative splicing events in the adaptive strategies of two Daphnia galeata genotypes induced by fish kairomones.BMC genomics · 2024Article
- Differential gene expression in response to fungal pathogen exposure in the aquatic invertebrate,Ecology and evolution · 2023Article
- Analysis of the complete mitogenome of Daphnia galeata from the Han River, South Korea: structure comparison and control region evolution.Functional & integrative genomics · 2023Article
- Infection by a eukaryotic gut parasite in wild Daphnia sp. associates with a distinct bacterial community.FEMS microbiology ecology · 2022Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundRegulatory circuits of infection in the emerging experimental model system, water flea Daphnia and their microparasites, remain largely unknown. Here we provide the first molecular insights into the response of Daphnia galeata to its highly virulent and common parasite Caullerya mesnili, an ichthyosporean that infects the gut epithelium. We generated a transcriptomic dataset using RNAseq from parasite-exposed (vs. control) Daphnia, at two time points (4 and 48 h) after parasite exposure.
resultsWe found a down-regulation of metabolism and immunity-related genes, at 48 h (but not 4 h) after parasite exposure. These genes are involved in lipid metabolism and fatty acid biosynthesis, as well as microbe recognition (e.g. c-type lectins) and pathogen attack (e.g. gut chitin).
conclusionsGeneral metabolic suppression implies host energy shift from reproduction to survival, which is in agreement with the known drastic reduction in Daphnia fecundity after Caullerya infection. The down-regulation of gut chitin indicates a possible interaction between the peritrophic matrix and the evading host immune system. Our study provides the first description of host transcriptional responses in this very promising host-parasite experimental system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.