Evidence map›Paper›PMID 30547392›Full record

ArticleSurgical endoscopy2019

Ultrasound shear wave elastography effectively predicts integrity of ventral hernia repair using acellular dermal matrix augmented with platelet-rich plasma (PRP).

Jeffrey L Van Eps, Anuj Chaudhry, Joseph S Fernandez-Moure, Christian Boada, Vishwanath Chegireddy, Fernando J Cabrera, Songyuan Tang, Ennio Tasciotti, Raffaella Righetti

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Article in Surgical endoscopy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jeffrey L Van EpsDepartment of Surgery, Houston Methodist Hospital, Houston, TX, USA.
Anuj ChaudhryDepartment of Electrical and Computer Engineering, Texas A&M University, College Station, TX, 77843-3128, USA.
Joseph S Fernandez-MoureDepartment of Surgery, Houston Methodist Hospital, Houston, TX, USA.
Christian BoadaCenter for Biomimetic Medicine, Houston Methodist Hospital Research Institute, Houston, TX, USA.
Vishwanath ChegireddyDepartment of Surgery, Houston Methodist Hospital, Houston, TX, USA.
Fernando J CabreraCenter for Biomimetic Medicine, Houston Methodist Hospital Research Institute, Houston, TX, USA.
Songyuan TangDepartment of Electrical and Computer Engineering, Texas A&M University, College Station, TX, 77843-3128, USA.
Ennio TasciottiCenter for Biomimetic Medicine, Houston Methodist Hospital Research Institute, Houston, TX, USA.
Raffaella RighettiDepartment of Electrical and Computer Engineering, Texas A&M University, 309D Wisenbaker Engineering Research Center, College Station, TX, 77843-3128, USA. righetti@ece.tamu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundComplications of ventral hernia repair (VHR) may be investigated by computed tomography or ultrasound (US) but neither modality gives a quantifiable metric of repair quality short of identifying hernia recurrence. Platelet-rich plasma (PRP), a growth factor-rich autologous blood product, has been shown to improve incorporation of native tissue with bioprosthetics. In this study, we investigate the effect of PRP on the incorporation and mechanical integrity of a non-crosslinked porcine acellular dermal matrix (pADM) in a rodent model of VHR and the correlative ability of ultrasound shear wave elastography (US-SWE) to assess repair quality.

methodsPRP was isolated from whole blood of Lewis rats. Twenty-eight Lewis rats underwent chronic VHR using either pADM alone or augmented with autologous PRP prior to non-invasive imaging assessment and specimen harvest at either 3 or 6 months. US-SWE was performed to estimate the Young's modulus prior to histological assessment and data from PRP-treated rodents were compared to controls.

resultsImplanted pADM was easily distinguishable by US-SWE imaging in all cases analyzed in this study. The mean Young's modulus measured was 1.78 times and 2.54 times higher in PRP-treated samples versus control at 3-month and 6-month time points respectively (p < 0.05). At 3 months, qualitative and quantitative histology revealed decreased inflammation and improved incorporation in PRP-treated samples along the implant/abdominal wall interface. At 6 months, the PRP cohort had no hernia recurrence and preserved ADM integrity from immunologic degradation, while all control animals suffered hernia recurrence (4/6) or extreme ADM thinning (2/6).

conclusionThis study confirms both the efficacy of PRP in augmenting VHR using pADM, as well as the reliability of US-SWE to non-invasively predict the quality of VHR. Although further human studies are necessary, this work supports PRP use to improve VHR outcomes and US-SWE potential for bedside non-invasive hernia characterization.

Indexed as

Acellular DermisPlatelet-Rich PlasmaSurgical MeshAnimalsDisease Models, AnimalElasticity Imaging TechniquesHernia, VentralHerniorrhaphyMalePredictive Value of TestsRatsRats, Inbred LewAcellular dermal matrixHerniaPlatelet-rich plasmaShear wave elastographyUltrasoundVentral hernia repair

Identifiers

PMID30547392

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.