Evidence map›Paper›PMID 30547319›Full record

ReviewGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2019

Interferon-α-induced retinopathy in chronic hepatitis C treatment: summary, considerations, and recommendations.

Zubir S Rentiya, Matthew Wells, Junun Bae, Kuan-Jen Chen, An-Ning Chao, Nicholas Turgeon, Syed M Shah, Mostafa Hanout

Abstract readReview
PubMed Publisher
In one paragraph

Review in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. [Toxic retinopathies].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2020
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Zubir S RentiyaDepartment of Radiology, Neurology, Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Matthew WellsLake Erie College of Osteopathic Medicine, Erie, PA, USA.
Junun BaeDepartment of Radiology, Neurology, Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kuan-Jen ChenDepartment of Ophthalmology, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan.
An-Ning ChaoDepartment of Ophthalmology, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan.
Nicholas TurgeonLake Erie College of Osteopathic Medicine, Erie, PA, USA.
Syed M ShahDepartment of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Mostafa HanoutDepartment of Ophthalmology and Vision Sciences, Princess Margaret Hospital/University Health Network, University of Toronto, 610 University Avenue, Toronto, ON, M5G 2M9, Canada. Mostafa.hanout@gmail.com.ORCID http://orcid.org/0000-0001-7829-9776
Chang Gung University · TWJohns Hopkins University · USLake Erie College of Osteopathic Medicine · USUniversity Health Network · CAUniversity of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interferons are cytokines that regulate the host's response to viral infection, particularly in the setting of the immunologic response to the hepatitis C virus (HCV). While the virus has the ability to evade the host's innate and specific immunity, exogenous interferon-α with combined ribavirin, treatments have been found to achieve a significant sustained viral response in subgroups of patients with chronic HCV. One of the major side effects of interferon-α is an ocular retinopathy characterized by flame-shaped hemorrhages and cotton wool spots visualized on funduscopic examination. There have been documented cases of more severe side effects including optic nerve and retinal artery damage; however, these instances are the minority. We sought to investigate the literature surrounding interferon-induced retinopathy, clinically correlate our findings with two recent cases, and provide recommendations for practitioners who continue to manage chronic HCV patients using interferon-α with combined ribavirin treatments.

Indexed as

Practice Guidelines as TopicAntiviral AgentsHepatitis C, ChronicHumansInterferon-alphaRetinaRetinal DiseasesTomography, Optical CoherenceAntiviral AgentsInterferon-alphaFundoscopic imagingHepatitis CInterferonMacular edemaNeuropathyOcular toxicityOptical coherence tomographyRetinopathy

Identifiers

PMID30547319
OpenAlexW2903893273

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.