Evidence map›Paper›PMID 30547285›Full record

ArticleMetabolic brain disease2019

Behavioral and electrophysiological brain effects of aspartame on well-nourished and malnourished rats.

Paula Catirina Germano Magalhães, Ricardo Abadie-Guedes, Manoel Augusto Barbosa da Costa Mendonça, Aline Duarte de Souza, Rubem Carlos Araújo Guedes

Abstract read
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In one paragraph

Article in Metabolic brain disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Reply to Charles V. Vorhees: Aspartame and anxiety-like behavior.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Paula Catirina Germano MagalhãesDepartamento de Nutrição, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil.
Ricardo Abadie-GuedesDepartamento de Fisiologia e Farmacologia, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil.
Manoel Augusto Barbosa da Costa MendonçaDepartamento de Nutrição, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil.
Aline Duarte de SouzaDepartamento de Nutrição, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil.
Rubem Carlos Araújo GuedesDepartamento de Nutrição, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil. guedes.rca@gmail.com.ORCID http://orcid.org/0000-0002-2396-4019
Universidade Federal de Pernambuco · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The non-caloric sweetener aspartame can be potentially harmful to the developing brain, as some studies suggest an association between aspartame intake and adverse neural effects. This study aimed to evaluate the possible effects of aspartame, with or without associated early nutritional deficiency, on behavioral parameters suggestive of anxiety and electrophysiological features of the excitability-related phenomenon known as cortical spreading depression (CSD). Newborn Wistar rats (n = 80) were suckled under favorable (L

Indexed as

AnimalsAnimals, NewbornAnxietyAspartameBehavior, AnimalBody WeightBrainCortical Spreading DepressionElectrophysiological PhenomenaLactationMaleRats, WistarAspartameAnxietyAspartameBrain excitabilityLactation conditionsNervous systemSpreading depression

Identifiers

PMID30547285
OpenAlexW2905562361

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.