Evidence map›Paper›PMID 30547182›Full record

ReviewSeminars in immunopathology2019

Sex differences in vaccine-induced humoral immunity.

Stephanie Fischinger, Carolyn M Boudreau, Audrey L Butler, Hendrik Streeck, Galit Alter

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Seminars in immunopathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 258 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
258citing papers in PubMed, 1 pooled it
18.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

258 citing papers in PubMed, 1 synthesis or guideline pooled it, 422 citations in OpenAlex.

  1. Pooled it
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  3. Randomized, Double-Blind, Placebo-Controlled Trial of MUC1 Peptide Vaccine for Prevention of Recurrent Colorectal Adenoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
    Trial
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  5. A self-amplifying mRNA SARS-CoV-2 vaccine candidate induces safe and robust protective immunity in preclinical models.Molecular therapy : the journal of the American Society of Gene Therapy · 2022
    Trial
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198 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Stephanie FischingerRagon Institute of MGH, MIT, and Harvard, 400 Technology Square, Cambridge, MA, 02139, USA.
Carolyn M BoudreauRagon Institute of MGH, MIT, and Harvard, 400 Technology Square, Cambridge, MA, 02139, USA.
Audrey L ButlerRagon Institute of MGH, MIT, and Harvard, 400 Technology Square, Cambridge, MA, 02139, USA.
Hendrik StreeckInstitut für HIV Forschung, Universität Duisburg-Essen, Duisburg, Germany.
Galit AlterRagon Institute of MGH, MIT, and Harvard, 400 Technology Square, Cambridge, MA, 02139, USA. galter@mgh.harvard.edu.
Ragon Institute of MGH, MIT and Harvard · USUniversity of Duisburg-Essen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccines are among the most impactful public health interventions, preventing millions of new infections and deaths annually worldwide. However, emerging data suggest that vaccines may not protect all populations equally. Specifically, studies analyzing variation in vaccine-induced immunity have pointed to the critical impact of genetics, the environment, nutrition, the microbiome, and sex in influencing vaccine responsiveness. The significant contribution of sex to modulating vaccine-induced immunity has gained attention over the last years. Specifically, females typically develop higher antibody responses and experience more adverse events following vaccination than males. This enhanced immune reactogenicity among females is thought to render females more resistant to infectious diseases, but conversely also contribute to higher incidence of autoimmunity among women. Dissection of mechanisms which underlie sex differences in vaccine-induced immunity has implicated hormonal, genetic, and microbiota differences across males and females. This review will highlight the importance of sex-dependent differences in vaccine-induced immunity and specifically will address the role of sex as a modulator of humoral immunity, key to long-term pathogen-specific protection.

Indexed as

Antibody FormationImmunity, HumoralSex CharacteristicsVaccinationVaccinesAutoimmune DiseasesFemaleHumansIncidenceInfection ControlInfectionsMaleMicrobiotaVaccinesGender differencesHormonesImmune responseInfectionSex differencesVaccination

Identifiers

PMID30547182
PMCPMC6373179
OpenAlexW2905444998

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.