ArticleJCO clinical cancer informatics2018
Development of a Medicare Health Outcomes Survey Deficit-Accumulation Frailty Index and Its Application to Older Patients With Newly Diagnosed Multiple Myeloma.
Article in JCO clinical cancer informatics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Trial
- Improving the identification of frail elderly newly diagnosed multiple myeloma patients.Leukemia · 2021Trial
- Trial
- Review
- Cumulative deficits frailty index and relationship status predict survival in multiple myeloma.Blood advances · 2025Article
- Prognostic Frailty-Based Determinants of Long-Term Mortality in Older Patients with Newly Diagnosed Multiple Myeloma.Cancers · 2025Article
- Functional Status Associations With Treatment Receipt and Outcomes Among Older Adults Newly Diagnosed With Multiple Myeloma.JCO clinical cancer informatics · 2024Article
- Measuring Frailty Using Patient-Reported Outcomes (PRO) Data: A Feasibility Study in Patients with Multiple Myeloma.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
- Dynamic frailty risk assessment among older adults with multiple myeloma: A population-based cohort study.Blood cancer journal · 2023Article
- Validating biologic age in selecting elderly patients with pancreatic cancer for surgical resection.Journal of surgical oncology · 2023Article
- Physical functioning, frailty and risks of locally-advanced breast cancer among older women.Breast (Edinburgh, Scotland) · 2022Article
- Prognostic value of the veterans affairs frailty index in older patients with non-small cell lung cancer.Cancer medicine · 2022Article
- Health-related Quality of Life in Hormone Receptor-Positive Early Breast Cancer: Analyses From the Surveillance, Epidemiology, and End Results Medicare Health Outcomes Survey.Journal of patient experience · 2022Article
- Review
- A deficit-accumulation frailty index predicts survival outcomes in patients with gynecologic malignancy.Gynecologic oncology · 2021Article
- Efficacy and safety profile of deep responders to carfilzomib-based therapy: a subgroup analysis from ASPIRE and ENDEAVOR.Leukemia · 2021Article
- Geriatric assessment and quality of life changes in older adults with newly diagnosed multiple myeloma undergoing treatment.Journal of geriatric oncology · 2020Article
- Depressive symptoms, mental health-related quality of life, and survival among older patients with multiple myeloma.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Article
- Self-reported health and survival in older patients diagnosed with multiple myeloma.Cancer causes & control : CCC · 2020Article
- Caring for older adults with multiple myeloma during the COVID-19 Pandemic: Perspective from the International Forum for Optimizing Care of Older Adults with Myeloma.Journal of geriatric oncology · 2020Article
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3 authors.
Funding
Abstract
Purpose: To develop a frailty index using the Rockwood Accumulation of Deficits approach for the Medicare Health Outcomes Survey (MHOS) and apply it in a subset of older patients with newly diagnosed multiple myeloma. Methods: Data from 2,692,361 patients without cancer, > 66 years of age, in SEER-MHOS linked databases between 1998 and 2009 were analyzed. A frailty index was constructed, resulting in a 25-item scale; cutoff values were created for individuals classified as frail. This frailty index was then applied to 305 patients with newly diagnosed myeloma in the database to predict overall survival. Results: In the derivation cohort of patients without cancer, the median age was 74 years and the mean frailty index was 0.23 (standard deviation, 0.17). Among patients without cancer, each 10% increase in frailty index (approximately three to four more deficits) was associated with a 40% increased risk for death (adjusted hazard ratio, 1.397; 95% CI, 1.396 to 1.399; Conclusion: The MHOS-based frailty index was prognostic for patients with multiple myeloma in predicting overall survival.
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