ArticleOrthopaedic journal of sports medicine2018
Foreign Body Reaction Associated With Artificial LARS Ligaments: A Retrieval Study.
Article in Orthopaedic journal of sports medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- The use of a synthetic shoulder patch for large and massive rotator cuff tears - a feasibility study.BMC musculoskeletal disorders · 2020Trial
- Effectiveness of synthetic vs. autologous ligaments in anterior cruciate ligament reconstruction with remnant preservation: a retrospective cohort study.Frontiers in sports and active living · 2026Article
- Advantages and Disadvantages of the Arthroscopic Procedure in Acromioclavicular Separation.Journal of clinical medicine · 2025Article
- 8-11 year results of LARS augmented hamstring in anterior cruciate ligament reconstruction surgery: Incidence of synovitis and failures.Journal of orthopaedics · 2025Article
- Acromioclavicular Reconstruction Using the Lockdown Technique: A Case Series and Systematic Review.Journal of clinical medicine · 2025Review
- Anterior Cruciate Ligament Reconstruction with LARS Synthetic Ligament: Outcomes and Failures.Journal of clinical medicine · 2024Article
- Surgical Advances in the Treatment of Acromioclavicular Joint Injury: A Comprehensive Review.Medical science monitor : international medical journal of experimental and clinical research · 2024Review
- Evaluation of biomechanical properties and biocompatibility: are partially absorbable cords eligible for anterior cruciate ligament reconstruction?Frontiers in bioengineering and biotechnology · 2023Article
- Anterior Cruciate Ligament Reconstruction with Quadrupled Semitendinosus Graft or Synthetic Ligament: Knee Stability and Clinical Outcomes at Three Years Follow-Up.Advances in orthopedics · 2023Article
- Massive foreign body reaction and osteolysis following primary anterior cruciate ligament reconstruction with the ligament augmentation and reconstruction system (LARS): a case report with histopathological and physicochemical analysis.BMC musculoskeletal disorders · 2022Article
- Periacetabular Tumour Resection under Anterosuperior Iliac Spine Allows Better Alloprosthetic Reconstruction than Above: Bone Contact Matters.Journal of clinical medicine · 2022Article
- Article
- Current concepts in graft selection for anterior cruciate ligament reconstruction.EFORT open reviews · 2021Review
- Differences in artificial ligament graft osseointegration of the anterior cruciate ligament in a sheep model: a comparison between interference screw and cortical suspensory fixation.Annals of translational medicine · 2021Article
- The Infinity-Lock System for Chronic Grade III AC Joint Dislocation: A Novel Technique, Rehabilitation Protocol and Short Term Results.Journal of clinical medicine · 2020Article
- Optimal Management of Acromioclavicular Dislocation: Current Perspectives.Orthopedic research and reviews · 2020Review
- Generation of a tendon-like tissue from human iPS cells.Journal of tissue engineeringArticle
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundArtificial ligaments have been developed and used in the treatment of ligamentous injuries since the 1970s. The early generation of artificial ligaments showed promising short-term results but resulted in high rates of rupture and inflammatory reaction in the surrounding tissues. PURPOSE: To determine whether the use of Ligament Augmentation and Reconstruction System (LARS) ligaments is associated with the development of intra-articular foreign body reaction. STUDY
designCase series; Level of evidence, 4.
methodsLARS ligaments were explanted from 15 patients under 6 consultant orthopaedic surgeons at 8 surgical centers. Of these, 14 explanted samples were sent for macroscopic and histological analysis, with the 1 remaining sample sent for scanning electron microscopy, to assess for inflammatory change as well as the degree of fibrous tissue ingrowth.
resultsWe observed a foreign body reaction in 10 of 14 explanted LARS ligaments. Seven samples demonstrated fibrous tissue ingrowth, with 5 producing only focal or incomplete ingrowth. The 2 samples with extensive fibrous coverage were completely free of any foreign body reaction, while all 5 remaining samples with only focal or partial fibrous ingrowth were associated with at least some degree of harmful immune response.
conclusionThe LARS ligament is still associated with a clinically significant degree of foreign body reaction despite the LARS Company's efforts to reduce complications through improved design. The development and completion of fibrous tissue ingrowth may work to reduce the occurrence of a foreign body reaction.
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