Evidence map›Paper›PMID 30547030›Full record

ArticleFrontiers in medicine2018

Feasibility Study of a Small Animal PET Insert Based on a Single LYSO Monolithic Tube.

Antonio J Gonzalez, Stuart S Berr, Gabriel Cañizares, Andrea Gonzalez-Montoro, Abel Orero, Carlos Correcher, Ahmadreza Rezaei, Johan Nuyts, Filomeno Sanchez, Stan Majewski and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Experimental validation of a rodent PET scanner prototype based on a single LYSO crystal tube.IEEE transactions on radiation and plasma medical sciences · 2022
    Article
  3. Article
  4. Article
  5. Article
  6. Multiplexing Readout for Time-of-Flight (TOF) PET Detectors Using Striplines.IEEE transactions on radiation and plasma medical sciences · 2021
    Article
  7. Article
  8. Article
  9. Calibration Methodology of an Edgeless PET System Prototype.IEEE Nuclear Science Symposium conference record. Nuclear Science Symposium
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Antonio J GonzalezDetector for Molecular Imaging Lab (DMIL), Instituto de Instrumentacion para Imagen Molecular (i3M), Centro Mixto CSIC - Universitat Politècnica de València, Valencia, Spain.
Stuart S BerrDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States.
Gabriel CañizaresDetector for Molecular Imaging Lab (DMIL), Instituto de Instrumentacion para Imagen Molecular (i3M), Centro Mixto CSIC - Universitat Politècnica de València, Valencia, Spain.
Andrea Gonzalez-MontoroDetector for Molecular Imaging Lab (DMIL), Instituto de Instrumentacion para Imagen Molecular (i3M), Centro Mixto CSIC - Universitat Politècnica de València, Valencia, Spain.
Abel OreroBruker NMI, Valencia, Spain.
Carlos CorrecherBruker NMI, Valencia, Spain.
Ahmadreza RezaeiNuclear Medicine and Medical Imaging Research Center KU Leuven, Leuven, Belgium.
Johan NuytsNuclear Medicine and Medical Imaging Research Center KU Leuven, Leuven, Belgium.
Filomeno SanchezDetector for Molecular Imaging Lab (DMIL), Instituto de Instrumentacion para Imagen Molecular (i3M), Centro Mixto CSIC - Universitat Politècnica de València, Valencia, Spain.
Stan MajewskiDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States.
Jose M BenllochDetector for Molecular Imaging Lab (DMIL), Instituto de Instrumentacion para Imagen Molecular (i3M), Centro Mixto CSIC - Universitat Politècnica de València, Valencia, Spain.
Instituto de Instrumentación para Imagen Molecular · ESKU Leuven · BEUniversity of Virginia · USUniversitat Politècnica de València · ES

Funding

Trimodal PET/SPECT/CT Preclinical Scanner for Biomedical ResearchS10OD021672 · OD · UNIVERSITY OF VIRGINIA · PI BERR, STUART S. · 2016 to 2016
$1.2M
NIH HHS S10 OD021672
6 · The paper itself

Abstract

There are drawbacks with using a Positron Emission Tomography (PET) scanner design employing the traditional arrangement of multiple detectors in an array format. Typically PET systems are constructed with many regular gaps between the detector modules in a ring or box configuration, with additional axial gaps between the rings. Although this has been significantly reduced with the use of the compact high granularity SiPM photodetector technology, such a scanner design leads to a decrease in the number of annihilation photons that are detected causing lower scanner sensitivity. Moreover, the ability to precisely determine the line of response (LOR) along which the positron annihilated is diminished closer to the detector edges because the spatial resolution there is degraded due to edge effects. This happens for both monolithic based designs, caused by the truncation of the scintillation light distribution, but also for detector blocks that use crystal arrays with a number of elements that are larger than the number of photosensors and, therefore, make use of the light sharing principle. In this report we present a design for a small-animal PET scanner based on a single monolithic annulus-like scintillator that can be used as a PET insert in high-field Magnetic Resonance systems. We provide real data showing the performance improvement when edge-less modules are used. We also describe the specific proposed design for a rodent scanner that employs facetted outside faces in a single LYSO tube. In a further step, in order to support and prove the proposed edgeless geometry, simulations of that scanner have been performed and lately reconstructed showing the advantages of the design.

Indexed as

hybrid PET-MRmonolithic crystalPositron emission tomographyPreclinical imagingSiPM

Identifiers

PMID30547030
PMCPMC6279866
OpenAlexW2903091129

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.