Evidence map›Paper›PMID 30546950›Full record

ArticleOncoimmunology

B cells in esophago-gastric adenocarcinoma are highly differentiated, organize in tertiary lymphoid structures and produce tumor-specific antibodies.

Hans A Schlößer, Martin Thelen, Axel Lechner, Kerstin Wennhold, Maria A Garcia-Marquez, Sacha I Rothschild, Elena Staib, Thomas Zander, Dirk Beutner, Birgit Gathof and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncoimmunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
1.9field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
  2. B cells in non-lymphoid tissues.Nature reviews. Immunology · 2025
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  7. Review
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  11. CD4Trends in cancer · 2024
    Review
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  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 3 countries.

Hans A SchlößerDepartment of General, Visceral and Cancer Surgery, University of Cologne, Cologne, Germany.
Martin ThelenCenter for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.
Axel LechnerCenter for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.
Kerstin WennholdCenter for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.
Maria A Garcia-MarquezCenter for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.
Sacha I RothschildDepartment of Oncology, University of Basel, Basel, Switzerland.
Elena StaibCenter for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.
Thomas ZanderDepartment I of Internal Medicine I, University of Cologne, Cologne, Germany.
Dirk BeutnerDepartment of Head and Neck Surgery, University of Göttingen, Göttingen, Germany.
Birgit GathofInstitute of Transfusion Medicine, University of Cologne, Cologne, Germany.
Ramona GillesInstitute of Transfusion Medicine, University of Cologne, Cologne, Germany.
Engin CukurogluGenome Institute of Singapore, Singapore, Singapore.
Jonathan GökeGenome Institute of Singapore, Singapore, Singapore.
Alexander Shimabukuro-VornhagenDepartment I of Internal Medicine I, University of Cologne, Cologne, Germany.
Uta DrebberInstitute of Pathology, University of Cologne, Cologne, Germany.
Alexander QuaasInstitute of Pathology, University of Cologne, Cologne, Germany.
Christiane J BrunsDepartment of General, Visceral and Cancer Surgery, University of Cologne, Cologne, Germany.
Arnulf H HölscherDepartment of General, Visceral and Cancer Surgery, University of Cologne, Cologne, Germany.
Michael S Von Bergwelt-BaildonGerman Cancer Consortium (DKTK), Heidelberg, Germany.
University of Cologne · DEGenome Institute of Singapore · SGUniversity of Göttingen · DEMünchen Klinik · DEUniversity of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor-infiltrating lymphocytes (TILs) are correlated to prognosis of several kinds of cancer. Most studies focused on T cells, while the role of tumor-associated B cells (TABs) has only recently gained more attention. TABs contain subpopulations with distinct functions, potentially promoting or inhibiting immune responses. This study provides a detailed analysis of TABs in gastro-esophageal adenocarcinoma (EAC). Flow cytometric analyses of single cell suspensions of tumor samples, mucosa, lymph nodes and peripheral blood mononuclear cells (PBMC) of EAC patients and healthy controls revealed a distinct B cell compartment in cancer patients. B cells were increased in tumor samples and subset-analyses of TILs showed increased proportions of differentiated and activated B cells and an enrichment for follicular T helper cells. Confocal microscopy demonstrated that TABs were mainly organized in tertiary lymphoid structures (TLS), which resemble lymphoid follicles in secondary lymphoid organs. A panel of 34 tumor-associated antigens (TAAs) expressed in EAC was identified based on public databases and TCGA data to analyze tumor-specific B cell responses using a LUMINEX

Indexed as

antibodyesophageal cancerPlasma cellstumor associated antigen

Identifiers

PMID30546950
PMCPMC6287776
OpenAlexW2899060037

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.