Evidence map›Paper›PMID 30546948›Full record

ArticleOncoimmunology

Ibrutinib significantly inhibited Bruton's tyrosine kinase (BTK) phosphorylation,

Yaya Chu, Sanghoon Lee, Tishi Shah, Changhong Yin, Matthew Barth, Rodney R Miles, Janet Ayello, Erin Morris, Lauren Harrison, Carmella Van de Ven and 8 more

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
  2. Lysine Targeting Group-Transfer Chimeras for Proximity Induction.Angewandte Chemie (International ed. in English) · 2026
    Article
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  7. Human Effectors of Acute and Chronic GVHD Overexpress CD83 and Predict Mortality.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
    Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 1 country.

Yaya ChuDepartment of Pediatrics, New York Medical College, Valhalla, NY, USA.
Sanghoon LeeDepartment of Pediatrics, New York Medical College, Valhalla, NY, USA.
Tishi ShahDepartment of Pediatrics, New York Medical College, Valhalla, NY, USA.
Changhong YinDepartment of Pediatrics, New York Medical College, Valhalla, NY, USA.
Matthew BarthDepartment of Pediatrics, University of Buffalo, Buffalo, NY, USA.
Rodney R MilesDepartment of Pathology, University of Utah, Salt Lake City, UT, USA.
Janet AyelloDepartment of Pediatrics, New York Medical College, Valhalla, NY, USA.
Erin MorrisDepartment of Pediatrics, New York Medical College, Valhalla, NY, USA.
Lauren HarrisonDepartment of Pediatrics, New York Medical College, Valhalla, NY, USA.
Carmella Van de VenDepartment of Pediatrics, New York Medical College, Valhalla, NY, USA.ORCID 0000-0001-7919-1089
Paul GalardyDepartment of Pediatrics, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-0322-8882
Stanton C GoldmanDivision of Pediatric Hematology/Oncology, Medical City Children's Hospital, Dallas, TX, USA.
Megan S LimDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, PA, USA.
Michelle HermistonDepartment of Pediatrics, University of California, San Francisco, CA, USA.
Linda M McAllister-LucasDepartment of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA.
Lisa Giulino-RothDepartments of Pediatrics and Pathology and Laboratory Medicine, Weill Cornell Medical College, NY, NY, USA.
Sherrie L PerkinsDepartment of Pathology, University of Utah, Salt Lake City, UT, USA.
Mitchell S CairoDepartment of Pediatrics, New York Medical College, Valhalla, NY, USA.
New York Medical College · USUniversity of Utah · USCornell University · USMayo Clinic in Arizona · USMedical City Children's Hospital · USUniversity at Buffalo, State University of New York · USUniversity of California, San Francisco · USUniversity of Pennsylvania · USUniversity of Pittsburgh · US

Funding

Rational Translation of EZH2 Targeted Therapy in Germinal Center B-cell LymphomaK08CA219473 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI ROTH, LISA GIULINO · 2017 to 2020
$684k
6 · The paper itself

Abstract

Pediatric and adult patients with recurrent/refractory Burkitt lymphoma (BL) continue to have poor outcomes, emphasizing the need for newer therapeutic agents. Bruton's tyrosine kinase (BTK) is activated following B-cell receptor stimulation and in part regulates normal B-cell development. Ibrutinib, a selective and irreversible BTK inhibitor, has been efficacious in chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), Waldenström's macroglobulinemia, and marginal zone lymphoma. In this study, we investigated the efficacy of ibrutinib alone and in selective adjuvant combinations against BL

Indexed as

Bruton’s Tyrosine KinaseBurkitt LymphomaCell ProliferationIbrutinibXenografted NSG Mice

Identifiers

PMID30546948
PMCPMC6287791
OpenAlexW2896117688

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.