Evidence map›Paper›PMID 30546920›Full record

ReviewBio-design and manufacturing2018

Multi-length scale bioprinting towards simulating microenvironmental cues.

Elisabeth L Gill, Xia Li, Mark A Birch, Yan Yan Shery Huang

Abstract readReview
In one paragraph

Review in Bio-design and manufacturing, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Elisabeth L Gill1Department of Engineering, University of Cambridge, Trumpington Street, Cambridge, CB2 1PZ UK.
Xia Li1Department of Engineering, University of Cambridge, Trumpington Street, Cambridge, CB2 1PZ UK.
Mark A Birch2Division of Trauma and Orthopaedic Surgery, Department of Surgery, University of Cambridge, Cambridge, UK.
Yan Yan Shery Huang1Department of Engineering, University of Cambridge, Trumpington Street, Cambridge, CB2 1PZ UK.

Funding

Medical Research Council MC_PC_12009
6 · The paper itself

Abstract

It is envisaged that the creation of cellular environments at multiple length scales, that recapitulate in vivo bioactive and structural roles, may hold the key to creating functional, complex tissues in the laboratory. This review considers recent advances in biofabrication and bioprinting techniques across different length scales. Particular focus is placed on 3D printing of hydrogels and fabrication of biomaterial fibres that could extend the feature resolution and material functionality of soft tissue constructs. The outlook from this review discusses how one might create and simulate microenvironmental cues in vitro. A fabrication platform that integrates the competencies of different biofabrication technologies is proposed. Such a multi-process, multiscale fabrication strategy may ultimately translate engineering capability into an accessible life sciences toolkit, fulfilling its potential to deliver in vitro disease models and engineered tissue implants.

Indexed as

3D bioprintingAdditive manufacturingDisease modellingElectrospinningMicroenvironmentTissue engineering

Identifiers

PMID30546920
PMCPMC6267274

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.